B6.129S1(Cg)-Slc6a4tm1(tTA)Cogr/Cnrm

Status

Available to order

EMMA IDEM:04891
Citation informationRRID:IMSR_EM:04891 

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International strain nameB6.129S1(Cg)-Slc6a4tm1(tTA)Cogr/Cnrm
Alternative nameSERT-tTA
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolSlc6a4tm1(tTA)Cogr
Gene/Transgene symbolSlc6a4

Information from provider

ProviderCornelius Gross
Provider affiliationMouse Biology Unit, European Molecular Biology Laboratory
Genetic informationA cassette containing the tetracycline trans-activator and a floxed neo were knocked into exon 2 at the translation initiation codon of the Slc6a4 (serotonin transporter, Sert) gene. In situ hybridization and autoradiography were used to confirm the absence of transcript and protein expression.
Phenotypic informationNo abnormal phenotype detected.
Breeding historyThe line was backcrossed in C57BL/6 for 12 generations and it is currently maintained by siblings breedings.
References
  • Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.;Audero Enrica, Coppi Elisabetta, Mlinar Boris, Rossetti Tiziana, Caprioli Antonio, Banchaabouchi Mumna Al, Corradetti Renato, Gross Cornelius, ;2008;Science (New York, N.Y.);321;130-3; 18599790
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • heart right ventricle hypertrophy / MGI
  • abnormal heart valve morphology / MGI
  • megacephaly / MGI
  • abnormal pulmonary artery morphology / MGI
  • abnormal social investigation / MGI
  • social withdrawal / MGI
  • abnormal anxiety-related response / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • abnormal response to new environment / MGI
  • decreased exploration in new environment / MGI
  • abnormal sleep pattern / MGI
  • abnormal body temperature homeostasis / MGI
  • abnormal fear/anxiety-related behavior / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • increased brain weight / MGI
  • behavioral despair / MGI
  • abnormal thermal nociception / MGI
  • dilated cardiomyopathy / MGI
  • abnormal active avoidance behavior / MGI
  • cardiac fibrosis / MGI
  • abnormal response to novel object / MGI
  • abnormal serotonergic neuron morphology / MGI
  • heart valve hyperplasia / MGI
  • abnormal barrel cortex morphology / MGI
  • abnormal neuron physiology / MGI
  • decreased cardiac muscle contractility / MGI
  • abnormal heart ventricle morphology / MGI
  • growth/size/body region phenotype / MGI
  • abnormal action potential / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • enhanced conditioned place preference behavior / MGI
  • impaired behavioral response to xenobiotic / MGI
  • decreased serotonin level / MGI
  • increased right ventricle systolic pressure / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI

Literature references

  • Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.;Audero Enrica, Coppi Elisabetta, Mlinar Boris, Rossetti Tiziana, Caprioli Antonio, Banchaabouchi Mumna Al, Corradetti Renato, Gross Cornelius, ;2008;Science (New York, N.Y.);321;130-3; 18599790

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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