MGI phenotypes (allele matching)
B6.129S1(Cg)-Slc6a4tm1(cre)Xz/Cnrm
| Status | Available to order |
| EMMA ID | EM:04890 |
| International strain name | B6.129S1(Cg)-Slc6a4tm1(cre)Xz/Cnrm |
| Alternative name | SERT-cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Slc6a4tm1(cre)Xz |
| Gene/Transgene symbol | Slc6a4 |
Information from provider
| Provider | Rene Hen |
| Provider affiliation | Columbia University |
| Genetic information | A targeting vector was constructed by inserting a cassette with the cre recombinase coding sequence, a nuclear translocation signal, and a PGK-neo gene flanked by FRT sites, into the 5'-UTR of the Slc6a4 (serotonin transporter, Sert) gene. After homologous recombination in ES cells, mice with cre recombinase expressed from the Slc6a4 locus were produced. Recombinase expression is detected in the Raphe nuclei. Knock-in mice were crossed with transgenic flp-deleter mice to remove the neo marker. |
| Phenotypic information | No abnormal phenotype detected. |
| Breeding history | The line was backcrossed to C57BL/6 for 15 generations and it is currently maintained by siblings breedings. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (gene matching)
- heart right ventricle hypertrophy / MGI
- abnormal heart valve morphology / MGI
- megacephaly / MGI
- abnormal pulmonary artery morphology / MGI
- abnormal social investigation / MGI
- social withdrawal / MGI
- abnormal anxiety-related response / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- abnormal response to new environment / MGI
- decreased exploration in new environment / MGI
- abnormal sleep pattern / MGI
- abnormal body temperature homeostasis / MGI
- abnormal fear/anxiety-related behavior / MGI
- abnormal brain morphology / MGI
- no abnormal phenotype detected / MGI
- increased brain weight / MGI
- behavioral despair / MGI
- abnormal thermal nociception / MGI
- dilated cardiomyopathy / MGI
- abnormal active avoidance behavior / MGI
- cardiac fibrosis / MGI
- abnormal response to novel object / MGI
- abnormal serotonergic neuron morphology / MGI
- heart valve hyperplasia / MGI
- abnormal barrel cortex morphology / MGI
- abnormal neuron physiology / MGI
- decreased cardiac muscle contractility / MGI
- abnormal heart ventricle morphology / MGI
- growth/size/body region phenotype / MGI
- abnormal action potential / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- enhanced conditioned place preference behavior / MGI
- impaired behavioral response to xenobiotic / MGI
- decreased serotonin level / MGI
- increased right ventricle systolic pressure / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
Literature references
- Targeted gene expression in dopamine and serotonin neurons of the mouse brain.;Zhuang Xiaoxi, Masson Justine, Gingrich Jay A, Rayport Stephen, Hen René, ;2005;Journal of neuroscience methods;143;27-32; 15763133
- Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants.;Korchynska Solomiia, Krassnitzer Maria, Malenczyk Katarzyna, Prasad Rashmi B, Tretiakov Evgenii O, Rehman Sabah, Cinquina Valentina, Gernedl Victoria, Farlik Matthias, Petersen Julian, Hannes Sophia, Schachenhofer Julia, Reisinger Sonali N, Zambon Alice, Asplund Olof, Artner Isabella, Keimpema Erik, Lubec Gert, Mulder Jan, Bock Christoph, Pollak Daniela D, Romanov Roman A, Pifl Christian, Groop Leif, Hökfelt Tomas Gm, Harkany Tibor, ;2020;The EMBO journal;39;e100882; 31750562
- STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology.;Reisinger Sonali N, Sideromenos Spyros, Horvath Orsolya, Derdak Sophia, Cicvaric Ana, Monje Francisco J, Bilban Martin, Häring Martin, Glat Micaela, Pollak Daniela D, ;2021;Molecular psychiatry;26;2886-2899; 33046834