C57BL/6NTac-Bmp7tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:04863
International strain nameC57BL/6NTac-Bmp7tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0510_3_C07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolBmp7tm1a(EUCOMM)Hmgu
Gene/Transgene symbolBmp7
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0510_3_C07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac
Breeding at archiving centreChimeras were mated to C57BL/6NTac USA and maintained on this background thereafter.

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased monocyte cell number / IMPC
  • increased mean corpuscular volume / IMPC
IMPC phenotypes (gene matching)
  • increased monocyte cell number / IMPC
  • increased mean corpuscular volume / IMPC
MGI phenotypes (gene matching)
  • abnormal cochlea morphology / MGI
  • delayed bone ossification / MGI
  • decreased bone mineral density / MGI
  • abnormal basioccipital bone morphology / MGI
  • abnormal basisphenoid bone morphology / MGI
  • cleft palate / MGI
  • growth retardation of molars / MGI
  • abnormal vertebrae morphology / MGI
  • rib bifurcation / MGI
  • rib fusion / MGI
  • abnormal sternum morphology / MGI
  • abnormal xiphoid process morphology / MGI
  • abnormal hair follicle morphology / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal cranium morphology / MGI
  • abnormal maxilla morphology / MGI
  • abnormal mandible morphology / MGI
  • abnormal kidney development / MGI
  • hydroureter / MGI
  • polydactyly / MGI
  • kinked tail / MGI
  • tremors / MGI
  • exencephaly / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal eye development / MGI
  • abnormal lens vesicle development / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • impaired coordination / MGI
  • abnormal apical ectodermal ridge morphology / MGI
  • premature death / MGI
  • abnormal vibrissa morphology / MGI
  • abnormal tooth morphology / MGI
  • abnormal digit morphology / MGI
  • abnormal axial skeleton morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal cricoid cartilage morphology / MGI
  • abnormal thyroid cartilage morphology / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal molar morphology / MGI
  • small kidney / MGI
  • abnormal sacral vertebrae morphology / MGI
  • abnormal hyoid bone morphology / MGI
  • aphakia / MGI
  • abnormal soft palate morphology / MGI
  • abnormal alisphenoid bone morphology / MGI
  • decreased rib number / MGI
  • renal hypoplasia / MGI
  • dilated renal glomerular capsule / MGI
  • kidney cysts / MGI
  • abnormal hard palate morphology / MGI
  • abnormal craniofacial development / MGI
  • decreased fetal size / MGI
  • small pterygoid bone / MGI
  • small basisphenoid bone / MGI
  • basisphenoid bone foramen / MGI
  • decreased renal glomerulus number / MGI
  • abnormal maxillary shelf morphology / MGI
  • broad limb buds / MGI
  • fusion of vertebral bodies / MGI
  • decreased lumbar vertebrae number / MGI
  • xiphoid process foramen / MGI
  • abnormal nasal capsule morphology / MGI
  • abnormal distal convoluted tubule morphology / MGI
  • absent upper incisors / MGI
  • abnormal retinal pigmentation / MGI
  • abnormal middle ear ossicle morphology / MGI
  • eyelids fail to open / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • abnormal renal glomerulus morphology / MGI
  • cardiovascular system phenotype / MGI
  • skeleton phenotype / MGI
  • abnormal skeleton morphology / MGI
  • retinal pigment epithelium atrophy / MGI
  • decreased molar number / MGI
  • asymmetric sternocostal joints / MGI
  • abnormal sternocostal joint morphology / MGI
  • polycystic kidney / MGI
  • abnormal vibrissa number / MGI
  • decreased birth weight / MGI
  • palatal shelf hypoplasia / MGI
  • palatal shelves fail to meet at midline / MGI
  • hair follicle outer root sheath hyperplasia / MGI
  • abnormal kidney mesenchyme morphology / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • decreased nephron number / MGI
  • absent metanephric mesenchyme / MGI
  • short rostral-caudal axis / MGI
  • small Meckel's cartilage / MGI
  • abnormal lower incisor morphology / MGI
  • abnormal nasal septum cartilage morphology / MGI
  • abnormal temporal bone petrous part morphology / MGI
  • absent thyroid cartilage / MGI
  • absent cricoid cartilage / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).