C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:04834
International strain nameC57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0557_4_E10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolElmod1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolElmod1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0557_4_E10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.;de Angelis Martin Hrabě, Nicholson George, Selloum Mohammed, White Jacqui, Morgan Hugh, Ramirez-Solis Ramiro, Sorg Tania, Wells Sara, Fuchs Helmut, Fray Martin, Adams David J, Adams Niels C, Adler Thure, Aguilar-Pimentel Antonio, Ali-Hadji Dalila, Amann Gregory, André Philippe, Atkins Sarah, Auburtin Aurelie, Ayadi Abdel, Becker Julien, Becker Lore, Bedu Elodie, Bekeredjian Raffi, Birling Marie-Christine, Blake Andrew, Bottomley Joanna, Bowl Mike, Brault Véronique, Busch Dirk H, Bussell James N, Calzada-Wack Julia, Cater Heather, Champy Marie-France, Charles Philippe, Chevalier Claire, Chiani Francesco, Codner Gemma F, Combe Roy, Cox Roger, Dalloneau Emilie, Dierich André, Di Fenza Armida, Doe Brendan, Duchon Arnaud, Eickelberg Oliver, Esapa Chris T, El Fertak Lahcen, Feigel Tanja, Emelyanova Irina, Estabel Jeanne, Favor Jack, Flenniken Ann, Gambadoro Alessia, Garrett Lilian, Gates Hilary, Gerdin Anna-Karin, Gkoutos George, Greenaway Simon, Glasl Lisa, Goetz Patrice, Da Cruz Isabelle Goncalves, Götz Alexander, Graw Jochen, Guimond Alain, Hans Wolfgang, Hicks Geoff, Hölter Sabine M, Höfler Heinz, Hancock John M, Hoehndorf Robert, Hough Tertius, Houghton Richard, Hurt Anja, Ivandic Boris, Jacobs Hughes, Jacquot Sylvie, Jones Nora, Karp Natasha A, Katus Hugo A, Kitchen Sharon, Klein-Rodewald Tanja, Klingenspor Martin, Klopstock Thomas, Lalanne Valerie, Leblanc Sophie, Lengger Christoph, le Marchand Elise, Ludwig Tonia, Lux Aline, McKerlie Colin, Maier Holger, Mandel Jean-Louis, Marschall Susan, Mark Manuel, Melvin David G, Meziane Hamid, Micklich Kateryna, Mittelhauser Christophe, Monassier Laurent, Moulaert David, Muller Stéphanie, Naton Beatrix, Neff Frauke, Nolan Patrick M, Nutter Lauryl Mj, Ollert Markus, Pavlovic Guillaume, Pellegata Natalia S, Peter Emilie, Petit-Demoulière Benoit, Pickard Amanda, Podrini Christine, Potter Paul, Pouilly Laurent, Puk Oliver, Richardson David, Rousseau Stephane, Quintanilla-Fend Leticia, Quwailid Mohamed M, Racz Ildiko, Rathkolb Birgit, Riet Fabrice, Rossant Janet, Roux Michel, Rozman Jan, Ryder Ed, Salisbury Jennifer, Santos Luis, Schäble Karl-Heinz, Schiller Evelyn, Schrewe Anja, Schulz Holger, Steinkamp Ralf, Simon Michelle, Stewart Michelle, Stöger Claudia, Stöger Tobias, Sun Minxuan, Sunter David, Teboul Lydia, Tilly Isabelle, Tocchini-Valentini Glauco P, Tost Monica, Treise Irina, Vasseur Laurent, Velot Emilie, Vogt-Weisenhorn Daniela, Wagner Christelle, Walling Alison, Weber Bruno, Wendling Olivia, Westerberg Henrik, Willershäuser Monja, Wolf Eckhard, Wolter Anne, Wood Joe, Wurst Wolfgang, Yildirim Ali Önder, Zeh Ramona, Zimmer Andreas, Zimprich Annemarie, null null, Holmes Chris, Steel Karen P, Herault Yann, Gailus-Durner Valérie, Mallon Ann-Marie, Brown Steve Dm, ;2015;Nature genetics;47;969-978; 26214591

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac
Breeding at archiving centreChimeras were backcrossed to C57BL/6N Tac (USA) and maintained on this background thereafter.

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating HDL cholesterol level / IMPC
  • decreased leukocyte cell number / IMPC
  • tremors / IMPC
  • abnormal gait / IMPC
  • abnormal startle reflex / IMPC
  • increased startle reflex / IMPC
  • trunk curl / IMPC
  • abnormal glucose homeostasis / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating chloride level / IMPC
  • thrombocytopenia / IMPC
  • abnormal locomotor activation / IMPC
  • decreased circulating glycerol level / IMPC
  • abnormal behavior / IMPC
  • decreased B cell number / IMPC
  • decreased circulating cholesterol level / IMPC
  • abnormal response to tactile stimuli / IMPC
  • increased blood urea nitrogen level / IMPC
  • impaired pupillary reflex / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased grip strength / IMPC
IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • decreased prepulse inhibition / IMPC
  • abnormal locomotor behavior / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal behavior / IMPC
  • increased startle reflex / IMPC
  • shortened PQ interval / IMPC
  • increased lean body mass / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased leukocyte cell number / IMPC
  • decreased thigmotaxis / IMPC
  • thrombocytopenia / IMPC
  • abnormal ear morphology / IMPC
  • decreased circulating glycerol level / IMPC
  • decreased large unstained cell number / IMPC
  • decreased locomotor activity / IMPC
  • abnormal startle reflex / IMPC
  • decreased circulating cholesterol level / IMPC
  • head bobbing / IMPC
  • abnormal gait / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased anxiety-related response / IMPC
  • abnormal glucose homeostasis / IMPC
  • impaired pupillary reflex / IMPC
  • decreased grip strength / IMPC
  • increased circulating phosphate level / IMPC
  • increased red blood cell distribution width / IMPC
  • trunk curl / IMPC
  • increased circulating chloride level / IMPC
  • increased blood urea nitrogen level / IMPC
  • increased eosinophil cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal response to tactile stimuli / IMPC
  • decreased B cell number / IMPC
  • abnormal locomotor activation / IMPC
  • tremors / IMPC
  • decreased monocyte cell number / IMPC
  • shortened PR interval / IMPC
  • decreased spleen weight / IMPC
  • decreased total body fat amount / IMPC
  • abnormal iris morphology / IMPC
  • increased heart rate variability / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased mean corpuscular volume / IMPC
  • cardiovascular system phenotype / IMPC
  • increased heart weight / IMPC
  • decreased startle reflex / IMPC
  • increased kidney weight / IMPC
MGI phenotypes (gene matching)
  • organ of Corti degeneration / MGI
  • circling / MGI
  • deafness / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • absent startle reflex / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Literature references

  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.;de Angelis Martin Hrabě, Nicholson George, Selloum Mohammed, White Jacqui, Morgan Hugh, Ramirez-Solis Ramiro, Sorg Tania, Wells Sara, Fuchs Helmut, Fray Martin, Adams David J, Adams Niels C, Adler Thure, Aguilar-Pimentel Antonio, Ali-Hadji Dalila, Amann Gregory, André Philippe, Atkins Sarah, Auburtin Aurelie, Ayadi Abdel, Becker Julien, Becker Lore, Bedu Elodie, Bekeredjian Raffi, Birling Marie-Christine, Blake Andrew, Bottomley Joanna, Bowl Mike, Brault Véronique, Busch Dirk H, Bussell James N, Calzada-Wack Julia, Cater Heather, Champy Marie-France, Charles Philippe, Chevalier Claire, Chiani Francesco, Codner Gemma F, Combe Roy, Cox Roger, Dalloneau Emilie, Dierich André, Di Fenza Armida, Doe Brendan, Duchon Arnaud, Eickelberg Oliver, Esapa Chris T, El Fertak Lahcen, Feigel Tanja, Emelyanova Irina, Estabel Jeanne, Favor Jack, Flenniken Ann, Gambadoro Alessia, Garrett Lilian, Gates Hilary, Gerdin Anna-Karin, Gkoutos George, Greenaway Simon, Glasl Lisa, Goetz Patrice, Da Cruz Isabelle Goncalves, Götz Alexander, Graw Jochen, Guimond Alain, Hans Wolfgang, Hicks Geoff, Hölter Sabine M, Höfler Heinz, Hancock John M, Hoehndorf Robert, Hough Tertius, Houghton Richard, Hurt Anja, Ivandic Boris, Jacobs Hughes, Jacquot Sylvie, Jones Nora, Karp Natasha A, Katus Hugo A, Kitchen Sharon, Klein-Rodewald Tanja, Klingenspor Martin, Klopstock Thomas, Lalanne Valerie, Leblanc Sophie, Lengger Christoph, le Marchand Elise, Ludwig Tonia, Lux Aline, McKerlie Colin, Maier Holger, Mandel Jean-Louis, Marschall Susan, Mark Manuel, Melvin David G, Meziane Hamid, Micklich Kateryna, Mittelhauser Christophe, Monassier Laurent, Moulaert David, Muller Stéphanie, Naton Beatrix, Neff Frauke, Nolan Patrick M, Nutter Lauryl Mj, Ollert Markus, Pavlovic Guillaume, Pellegata Natalia S, Peter Emilie, Petit-Demoulière Benoit, Pickard Amanda, Podrini Christine, Potter Paul, Pouilly Laurent, Puk Oliver, Richardson David, Rousseau Stephane, Quintanilla-Fend Leticia, Quwailid Mohamed M, Racz Ildiko, Rathkolb Birgit, Riet Fabrice, Rossant Janet, Roux Michel, Rozman Jan, Ryder Ed, Salisbury Jennifer, Santos Luis, Schäble Karl-Heinz, Schiller Evelyn, Schrewe Anja, Schulz Holger, Steinkamp Ralf, Simon Michelle, Stewart Michelle, Stöger Claudia, Stöger Tobias, Sun Minxuan, Sunter David, Teboul Lydia, Tilly Isabelle, Tocchini-Valentini Glauco P, Tost Monica, Treise Irina, Vasseur Laurent, Velot Emilie, Vogt-Weisenhorn Daniela, Wagner Christelle, Walling Alison, Weber Bruno, Wendling Olivia, Westerberg Henrik, Willershäuser Monja, Wolf Eckhard, Wolter Anne, Wood Joe, Wurst Wolfgang, Yildirim Ali Önder, Zeh Ramona, Zimmer Andreas, Zimprich Annemarie, null null, Holmes Chris, Steel Karen P, Herault Yann, Gailus-Durner Valérie, Mallon Ann-Marie, Brown Steve Dm, ;2015;Nature genetics;47;969-978; 26214591
  • Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain.;Wagner Elizabeth L, Im Jun-Sub, Sala Stefano, Nakahata Maura I, Imbery Terence E, Li Sihan, Chen Daniel, Nimchuk Katherine, Noy Yael, Archer David W, Xu Wenhao, Hashisaki George, Avraham Karen B, Oakes Patrick W, Shin Jung-Bum, ;2023;eLife;12;; 37294664

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