C57BL/6N-Slc40a1tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:04833
Citation informationRRID:IMSR_EM:04833 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Slc40a1tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0551_2_A07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSlc40a1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolSlc40a1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0551_2_A07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac males
Breeding at archiving centreChimeras were mated to C57BL/6N Tac USA and maintained on this background thereafter.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased bone mineral density / IMPC
  • increased total body fat amount / IMPC
  • decreased bone mineral content / IMPC
  • increased circulating triglyceride level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased lean body mass / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
MGI phenotypes (gene matching)
  • abnormal liver morphology / MGI
  • abnormal liver physiology / MGI
  • small spleen / MGI
  • microphthalmia / MGI
  • anemia / MGI
  • decreased embryo size / MGI
  • edema / MGI
  • abnormal pancreas morphology / MGI
  • premature death / MGI
  • abnormal erythrocyte morphology / MGI
  • abnormal macrophage physiology / MGI
  • increased mean corpuscular volume / MGI
  • decreased mean corpuscular volume / MGI
  • increased hematocrit / MGI
  • anisocytosis / MGI
  • polycythemia / MGI
  • decreased hemoglobin content / MGI
  • increased erythrocyte cell number / MGI
  • abnormal forebrain development / MGI
  • nervous system phenotype / MGI
  • oxidative stress / MGI
  • pallor / MGI
  • abnormal neural tube closure / MGI
  • decreased thermal nociceptive threshold / MGI
  • decreased circulating iron level / MGI
  • cachexia / MGI
  • abnormal enzyme/coenzyme level / MGI
  • homeostasis/metabolism phenotype / MGI
  • vision/eye phenotype / MGI
  • hematopoietic system phenotype / MGI
  • decreased mean corpuscular hemoglobin / MGI
  • increased hemoglobin content / MGI
  • abnormal iron homeostasis / MGI
  • hemochromatosis / MGI
  • hypochromic microcytic anemia / MGI
  • abnormal spleen physiology / MGI
  • decreased liver iron level / MGI
  • increased liver iron level / MGI
  • decreased spleen iron level / MGI
  • increased spleen iron level / MGI
  • increased circulating iron level / MGI
  • abnormal pancreatic acinar cell morphology / MGI
  • increased splenocyte apoptosis / MGI
  • abnormal spleen development / MGI
  • leptocytosis / MGI
  • increased kidney iron level / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
  • increased circulating lipase level / MGI
  • increased circulating ferritin level / MGI
  • increased circulating unsaturated transferrin level / MGI
  • decreased circulating unsaturated transferrin level / MGI
  • increased pancreas iron level / MGI
  • increased brain iron level / MGI
  • increased heart iron level / MGI
  • decreased intestinal iron level / MGI

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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Practical information

Genotyping protocol

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