C57BL/6N-Per2tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:04827
International strain nameC57BL/6N-Per2tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0553_1_A01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPer2tm1a(EUCOMM)Hmgu
Gene/Transgene symbolPer2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0553_1_A01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac
Breeding at archiving centreChimeras were mated to C57BL/6N Tac USA mice and maintained on this background thereafter.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal coat/hair pigmentation / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased lean body mass / IMPC
  • abnormal behavior / IMPC
IMPC phenotypes (gene matching)
  • increased lean body mass / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • abnormal behavior / IMPC
MGI phenotypes (gene matching)
  • salivary gland epithelial hyperplasia / MGI
  • abnormal body weight / MGI
  • increased body weight / MGI
  • abnormal retina morphology / MGI
  • pup cannibalization / MGI
  • abnormal food preference / MGI
  • abnormal sleep pattern / MGI
  • abnormal blood vessel morphology / MGI
  • increased mortality induced by gamma-irradiation / MGI
  • reduced female fertility / MGI
  • decreased litter size / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • abnormal bone marrow cell morphology/development / MGI
  • abnormal male preputial gland morphology / MGI
  • abnormal retinal vasculature morphology / MGI
  • no phenotypic analysis / MGI
  • decreased cellular sensitivity to gamma-irradiation / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system morphology / MGI
  • increased incidence of tumors by ionizing radiation induction / MGI
  • increased hematopoietic stem cell number / MGI
  • abnormal brain wave pattern / MGI
  • improved glucose tolerance / MGI
  • behavior/neurological phenotype / MGI
  • abnormal food intake / MGI
  • abnormal maternal behavior / MGI
  • abnormal basal metabolism / MGI
  • early reproductive senescence / MGI
  • prolonged estrous cycle / MGI
  • absent estrous cycle / MGI
  • abnormal pregnancy / MGI
  • enhanced conditioned place preference behavior / MGI
  • enhanced behavioral response to cocaine / MGI
  • increased salivary gland tumor incidence / MGI
  • abnormal hematopoietic stem cell physiology / MGI
  • increased bone volume / MGI
  • abnormal circadian temperature homeostasis / MGI
  • decreased hematopoietic stem cell proliferation / MGI
  • increased lymphoma incidence / MGI
  • increased bone ossification / MGI
  • abnormal circadian behavior / MGI
  • shortened circadian behavior period / MGI
  • arrhythmic circadian behavior persistence / MGI
  • delayed circadian behavior phase / MGI
  • abnormal locomotor circadian rhythm / MGI
  • abnormal circadian sleep/wake cycle / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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