IMPC phenotypes (gene matching)
C57BL/6N-Bag3tm1a(EUCOMM)Hmgu/H
| Status | Available to order |
| EMMA ID | EM:04807 |
| Citation information | RRID:IMSR_EM:04807 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Bag3tm1a(EUCOMM)Hmgu/H |
| Alternative name | HEPD0556_7_B06 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Bag3tm1a(EUCOMM)Hmgu |
| Gene/Transgene symbol | Bag3 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0556_7_B06. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTac males |
| Breeding at archiving centre | Chimeras were mated to C57BL/6N Tac USA and maintained on this background thereafter. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial isolated dilated cardiomyopathy / Orphanet_154
- Muscular dystrophy, Selcen type / Orphanet_199340
MGI phenotypes (gene matching)
- hypoglycemia / MGI
- decreased leukocyte cell number / MGI
- decreased neutrophil cell number / MGI
- pale liver / MGI
- spleen hypoplasia / MGI
- abnormal skeletal muscle morphology / MGI
- decreased body weight / MGI
- weight loss / MGI
- postnatal growth retardation / MGI
- thymus hypoplasia / MGI
- postnatal lethality / MGI
- premature death / MGI
- disproportionate dwarf / MGI
- increased circulating ketone body level / MGI
- hepatic steatosis / MGI
- decreased circulating triglyceride level / MGI
- decreased circulating insulin level / MGI
- no phenotypic analysis / MGI
- increased cardiomyocyte apoptosis / MGI
- decreased liver weight / MGI
- pulmonary edema / MGI
- abnormal Z line morphology / MGI
- myocardial fiber degeneration / MGI
- decreased spleen weight / MGI
- decreased thymus weight / MGI
- decreased lymphocyte cell number / MGI
- decreased circulating cholesterol level / MGI
- decreased subcutaneous adipose tissue amount / MGI
- decreased gonadal fat pad weight / MGI
- skeletal muscle fiber degeneration / MGI
- postnatal lethality, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI