MGI phenotypes (allele matching)
B6.Cg-Del(7Ifitm5-Ifitm6)1Masu Tyrc-Brd/Cnbc
| Status | Available to order |
| EMMA ID | EM:04804 |
| International strain name | B6.Cg-Del(7Ifitm5-Ifitm6)1Masu Tyrc-Brd/Cnbc |
| Alternative name | IfitmDel (MDAA) |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Del(7Ifitm5-Ifitm6)1Masu |
| Gene/Transgene symbol | Del(7Ifitm5-Ifitm6)1Masu |
Information from provider
| Provider | David Adams |
| Provider affiliation | Sanger Cryopreservation Unit, Wellcome Trust Sanger Institute |
| Genetic information | Targeted deletion of the Ifitm gene cluster. Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Lange UC, Adams DJ, Lee C, Barton S, Schneider R, Bradley A, Surani MA. Mol Cell Biol. 2008 Aug;28(15):4688-96. PMID: 18505827. |
| Phenotypic information | Viable, fertile. Role in viral infection. Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009 Dec 24;139(7):1243-54. PMID: 20064371. |
| Breeding history | Mutation was produced in E14 ES cells. Chimera were then bred with C57BL/6J mice for germline transmission. F1 mice were then crossed for 5 generations onto C57BL/6J-c/c mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous 0, wild-type C57BL/6J-Tyr |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.;Lange Ulrike C, Adams David J, Lee Caroline, Barton Sheila, Schneider Robert, Bradley Allan, Surani M Azim, ;2008;Molecular and cellular biology;28;4688-96; 18505827
- The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.;Brass Abraham L, Huang I-Chueh, Benita Yair, John Sinu P, Krishnan Manoj N, Feeley Eric M, Ryan Bethany J, Weyer Jessica L, van der Weyden Louise, Fikrig Erol, Adams David J, Xavier Ramnik J, Farzan Michael, Elledge Stephen J, ;2009;Cell;139;1243-54; 20064371