B6.129P2-Cd40tm1Kik/Orl

Status

Available to order

EMMA IDEM:00048
International strain nameB6.129P2-Cd40tm1Kik/Orl
Alternative nameCD40°
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCd40tm1Kik
Gene/Transgene symbolCd40

Information from provider

ProviderH Kikutani
Provider affiliationc/o CDTA-Orleans
Phenotypic informationMutant mice deficient in CD40 (TNFRSF5) expression at B-cell surface. Obtained by mutation of the Cd40 gene by homologous recombination (insertion of the neo gene into the third exon) in ES cells of 129 origin. The mutant mice have increased IgM responses but no IgG, IgA and IgE responses to thymus-dependent antigens. IgG and IgM responses to thymus-independent antigens are normal. The germinal center formation is absent in Cd40-deficient mice.
Breeding history129/Ola ES cells; crossed with C57BL/6 then backcrossed to N5.
References
  • The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.;Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H, ;1994;Immunity;1;167-78; 7534202

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased bone mineral density / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to bacterial infection / MGI
  • hematopoietic system phenotype / MGI
  • decreased cerebral infarction size / MGI
  • decreased platelet aggregation / MGI
  • decreased trabecular bone mass / MGI
  • decreased compact bone mass / MGI
  • decreased B cell number / MGI
  • immune system phenotype / MGI
  • absent germinal center B cells / MGI
  • decreased neutrophil cell number / MGI
  • abnormal humoral immune response / MGI
  • decreased IgA level / MGI
  • decreased immunoglobulin level / MGI
  • decreased IgE level / MGI
  • decreased susceptibility to type II hypersensitivity reaction / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • decreased neutrophil cell number / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to bacterial infection / MGI
  • decreased immunoglobulin level / MGI
  • abnormal immunoglobulin level / MGI
  • decreased IgE level / MGI
  • increased IgM level / MGI
  • decreased B cell number / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • decreased susceptibility to type II hypersensitivity reaction / MGI
  • abnormal response to transplant / MGI
  • decreased cerebral infarction size / MGI
  • absent germinal center B cells / MGI
  • absent spleen germinal center / MGI
  • decreased spleen germinal center number / MGI
  • decreased spleen germinal center size / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased IgG3 level / MGI
  • abnormal lymph node germinal center morphology / MGI
  • decreased platelet aggregation / MGI
  • decreased trabecular bone mass / MGI
  • decreased compact bone mass / MGI
  • impaired humoral immune response / MGI

Literature references

  • The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.;Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H, ;1994;Immunity;1;167-78; 7534202

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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