B6.Cg-Tg(Cr2-cre)3Cgn/Flmg
| Status | Available to order |
| EMMA ID | EM:04787 |
| International strain name | B6.Cg-Tg(Cr2-cre)3Cgn/Flmg |
| Alternative name | B6.CBA-CD21-Cre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Cr2-cre)3Cgn |
| Gene/Transgene symbol | Tg(Cr2-cre)3Cgn |
Information from provider
| Provider | George Kollias |
| Provider affiliation | B.S.R.C. |
| Additional owner | Prof. Klaus Rajewsky, Immune Disease Institute, Boston, MA |
| Genetic information | A targeting vector, containing the cre recombinase-encoding sequence and FRT-flanked kanamycin resistance gene, was inserted into a BAC clone carrying the murine Cr2 (CD21/CD35) gene. Kanamycin was excised and CD21-cre BAC was microinjected in mouse zygotes. |
| Phenotypic information | None. This strain expresses cre recombinase under murine Cr2 (CD21) promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, cre-mediated recombination results in deletion of the targeted sequence specifically in B lymphocytes and follicular dendritic cells (FDCs). This strain represents an effective tool for the generation of cell-specific targeted mutants. |
| References |
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Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Literature references
- FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.;Victoratos Panayiotis, Lagnel Jacques, Tzima Sotiria, Alimzhanov Marat B, Rajewsky Klaus, Pasparakis Manolis, Kollias George, ;2006;Immunity;24;65-77; 16413924
- Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer.;Kraus Manfred, Alimzhanov Marat B, Rajewsky Nikolaus, Rajewsky Klaus, ;2004;Cell;117;787-800; 15186779