- increased mean platelet volume / IMPC
- persistence of hyaloid vascular system / IMPC
- hyperactivity / IMPC
- decreased circulating serum albumin level / IMPC
- impaired righting response / IMPC
- abnormal vertebrae morphology / IMPC
- preweaning lethality, complete penetrance / IMPC
- increased circulating aspartate transaminase level / IMPC
B6;129-Klf7tm1Rmz/Cnrm
Status | Available to order |
EMMA ID | EM:04785 |
International strain name | B6;129-Klf7tm1Rmz/Cnrm |
Alternative name | Klf7 +/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Klf7tm1Rmz |
Gene/Transgene symbol | Klf7 |
Information from provider
Provider | Francesco Ramirez |
Provider affiliation | Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine |
Additional owner | Prof. Bruce Krueger, University of Maryland School of Medicine, Baltimore MD, U.S.A. |
Genetic information | The targeting vector was designed to replace most of exon 1 with the phosphoglycerate kinase (PGK)-neo cassette flanked by loxP sites. |
Phenotypic information | Klf7 +/- mice display no anatomical abnormalities and are fertile and viable. Klf7 knock-out mice die within 3 days after birth, displaying severely hypoplastic olfactory bulbs, and altered neuronal differentiation in the central nervous system. |
Breeding history | The strain was inbred for 4 generations. It is currently bred using Klf7 +/- males and wild-type females. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- abnormal nervous system tract morphology / MGI
- abnormal corpus callosum morphology / MGI
- abnormal telencephalon morphology / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal sensory neuron innervation pattern / MGI
- unresponsive to tactile stimuli / MGI
- cyanosis / MGI
- hypopnea / MGI
- abnormal brain morphology / MGI
- small olfactory bulb / MGI
- abnormal axon guidance / MGI
- abnormal hippocampal fimbria morphology / MGI
- abnormal axon extension / MGI
- abnormal olfactory nerve morphology / MGI
- absent anterior commissure / MGI
- absent gastric milk in neonates / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal olfactory neuron innervation pattern / MGI
MGI phenotypes (gene matching)
- abnormal nervous system tract morphology / MGI
- abnormal corpus callosum morphology / MGI
- abnormal telencephalon morphology / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal sensory neuron innervation pattern / MGI
- unresponsive to tactile stimuli / MGI
- cyanosis / MGI
- hypopnea / MGI
- abnormal brain morphology / MGI
- small olfactory bulb / MGI
- abnormal axon guidance / MGI
- abnormal hippocampal fimbria morphology / MGI
- abnormal axon extension / MGI
- abnormal olfactory nerve morphology / MGI
- absent anterior commissure / MGI
- absent gastric milk in neonates / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal olfactory neuron innervation pattern / MGI
Literature references
- Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.;Laub Friedrich, Lei Lei, Sumiyoshi Hideaki, Kajimura Daisuke, Dragomir Cecilia, Smaldone Silvia, Puche Adam C, Petros Timothy J, Mason Carol, Parada Luis F, Ramirez Francesco, ;2005;Molecular and cellular biology;25;5699-711; 15964824
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