B6Dnk;B6N-Rbfox3tm1a(EUCOMM)Hmgu/H
Status | Available to order |
EMMA ID | EM:04705 |
International strain name | B6Dnk;B6N-Rbfox3tm1a(EUCOMM)Hmgu/H |
Alternative name | HEPD0543_7_B10 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Rbfox3tm1a(EUCOMM)Hmgu |
Gene/Transgene symbol | Rbfox3 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | This mouse line originates from EUCOMM ES clone HEPD0543_7_B10. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | heterozygous C57BL/6Dnk |
Breeding at archiving centre | Chimeras were mated to C57BL/6N Tac Den and maintained on this background thereafter. |
Disease and phenotype information
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- decreased anxiety-related response / MGI
- hyperactivity / MGI
- abnormal object recognition memory / MGI
- reduced long term depression / MGI
- impaired synaptic plasticity / MGI
- decreased brain weight / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal thermal nociception / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- abnormal excitatory postsynaptic potential / MGI
- decreased paired-pulse facilitation / MGI
- nervous system phenotype / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- decreased neuronal precursor cell number / MGI
- behavior/neurological phenotype / MGI
- abnormal brain white matter morphology / MGI
- increased neurotransmitter release / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal dendritic spine morphology / MGI
- abnormal neuron differentiation / MGI
- abnormal hippocampus granule cell morphology / MGI
- abnormal hippocampus neuron morphology / MGI
- abnormal hippocampus physiology / MGI
- impaired spatial learning / MGI
- abnormal dentate gyrus neuron dendrite morphology / MGI
- abnormal excitatory synapse morphology / MGI
- decreased neuronal precursor proliferation / MGI
MGI phenotypes (gene matching)
- decreased anxiety-related response / MGI
- hyperactivity / MGI
- abnormal object recognition memory / MGI
- reduced long term depression / MGI
- impaired synaptic plasticity / MGI
- decreased brain weight / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal thermal nociception / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- abnormal excitatory postsynaptic potential / MGI
- decreased paired-pulse facilitation / MGI
- nervous system phenotype / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- decreased neuronal precursor cell number / MGI
- behavior/neurological phenotype / MGI
- abnormal brain white matter morphology / MGI
- increased neurotransmitter release / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal dendritic spine morphology / MGI
- abnormal neuron differentiation / MGI
- abnormal hippocampus granule cell morphology / MGI
- abnormal hippocampus neuron morphology / MGI
- abnormal hippocampus physiology / MGI
- impaired spatial learning / MGI
- abnormal dentate gyrus neuron dendrite morphology / MGI
- abnormal excitatory synapse morphology / MGI
- decreased neuronal precursor proliferation / MGI
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