MGI phenotypes (allele matching)
- immune system phenotype / MGI
B6.Cg-Klra5tm1.1Cgbr/H
| Status | Available to order |
| EMMA ID | EM:04669 |
| Citation information | RRID:IMSR_EM:04669 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Klra5tm1.1Cgbr/H |
| Alternative name | Ly49E-ko |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Klra5tm1.1Cgbr |
| Gene/Transgene symbol | Klra5 |
Information from provider
| Provider | Colin Brooks |
| Provider affiliation | University of Newcastle |
| Genetic information | C57BL/6 Klra5 (Ly49E) b-geo knock-in. |
| Phenotypic information | Lack of expression of Klra5 (Ly49E). Expression of b-geo. No other known phenotype at present. |
| Breeding history | Targeted C57BL/6 Bruce 4 ES cells were injected in B6 albino [B6(Cg)-Tyrc-2J/J] blastocysts, and the resulting chimeric animal was bred with FLP-deleter mice on a B6 background. Progeny of these animals that had deleted the selection cassette and possessed a Klra5 knock-out allele were interbred, and animals homozygous for the Klra5 knock-out allele were interbred. Animals are currently at their 4th generation of interbreeding. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6 males |
| Breeding at archiving centre | None |
Disease and phenotype information
Literature references
- Mice lacking Ly49E show normal NK cell development and provide evidence for probabilistic expression of Ly49E in NK cells and T cells.;Aust Jonathan G, Gays Frances, Hussain Farhana, Butcher Geoffrey W, Kist Ralf, Peters Heiko, Brooks Colin G, ;2011;Journal of immunology (Baltimore, Md. : 1950);186;2013-23; 21248256