MGI phenotypes (allele matching)
- immune system phenotype / MGI
B6.Cg-Klra5tm1.1Cgbr/H
| Status | Available to order |
| EMMA ID | EM:04669 |
| International strain name | B6.Cg-Klra5tm1.1Cgbr/H |
| Alternative name | Ly49E-ko |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Klra5tm1.1Cgbr |
| Gene/Transgene symbol | Klra5 |
Information from provider
| Provider | Colin Brooks |
| Provider affiliation | University of Newcastle |
| Genetic information | C57BL/6 Klra5 (Ly49E) b-geo knock-in. |
| Phenotypic information | Lack of expression of Klra5 (Ly49E). Expression of b-geo. No other known phenotype at present. |
| Breeding history | Targeted C57BL/6 Bruce 4 ES cells were injected in B6 albino [B6(Cg)-Tyrc-2J/J] blastocysts, and the resulting chimeric animal was bred with FLP-deleter mice on a B6 background. Progeny of these animals that had deleted the selection cassette and possessed a Klra5 knock-out allele were interbred, and animals homozygous for the Klra5 knock-out allele were interbred. Animals are currently at their 4th generation of interbreeding. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6 |
| Breeding at archiving centre | None |
Disease and phenotype information
Literature references
- Mice lacking Ly49E show normal NK cell development and provide evidence for probabilistic expression of Ly49E in NK cells and T cells.;Aust Jonathan G, Gays Frances, Hussain Farhana, Butcher Geoffrey W, Kist Ralf, Peters Heiko, Brooks Colin G, ;2011;Journal of immunology (Baltimore, Md. : 1950);186;2013-23; 21248256