STOCK Tg(tetO-AGTR1,-lacZ)1Aco/Cnbc
| Status | Available to order |
| EMMA ID | EM:04643 |
| International strain name | STOCK Tg(tetO-AGTR1,-lacZ)1Aco/Cnbc |
| Alternative name | ZhAT1Rwt1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-AGTR1,-lacZ)1Aco |
| Gene/Transgene symbol | Tg(tetO-AGTR1,-lacZ)1Aco |
Information from provider
| Provider | Justin Ainscough |
| Provider affiliation | Central Biomedical Services, University of Leeds |
| Genetic information | A lacZ reporter gene and the human angiotensin II type 1 receptor are expressed under control of a bidirectional minimal CMV promoter linked to a tet response element (TRE). Gene expression is induced in the presence of a transactivator molecule (tTA or rtTA), and can be regulated by doxycycline. |
| Phenotypic information | No phenotype in uninduced state. Induction of hAT1R expression in adult cardiomyocytes by crossing with alphaMHC tTA transactivator mice causes blood pressure-independent cardiac hypertrophy. Effects of activation in other tissues have not been tested. |
| Breeding history | The line was crossed with FVB transactivator mice and subsequently backcrossed for at least four generations onto C57BL/6. Currently maintained by inbreeding. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Literature references
- Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.;Ainscough Justin F X, Drinkhill Mark J, Sedo Alicia, Turner Neil A, Brooke David A, Balmforth Anthony J, Ball Stephen G, ;2009;Cardiovascular research;81;592-600; 18703536