B6.129-Scn10atm2(cre)Jwo/H

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Available to order

EMMA IDEM:04582
Citation informationRRID:IMSR_EM:04582 

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International strain nameB6.129-Scn10atm2(cre)Jwo/H
Alternative nameNav1.8Cre
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolScn10atm2(cre)Jwo
Gene/Transgene symbolScn10a

Information from provider

ProviderMohammed Nassar
Provider affiliationWindeyer Institute of Medical Sciences, University College London
Genetic informationcre recombinase is expressed from the Scn10a (Nav1.8) locus; expression of cre is restricted to sensory neurons.
Phenotypic informationNo phenotype in the heterozygotes. Some pain deficits in homozygotes.
Breeding historyBackcrossed to C57BL/6 from 129, inbred crossed for a few generations and then outcrossed to C57BL/6 every few generations. Currently inbred to keep homozygosity.
References
  • Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice.;Stirling L Caroline, Forlani Greta, Baker Mark D, Wood John N, Matthews Elizabeth A, Dickenson Anthony H, Nassar Mohammed A, ;2005;Pain;113;27-36; 15621361
  • Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling.;Megat Salim, Ray Pradipta R, Tavares-Ferreira Diana, Moy Jamie K, Sankaranarayanan Ishwarya, Wanghzou Andi, Fang Lou Tzu, Barragan-Iglesias Paulino, Campbell Zachary T, Dussor Gregory, Price Theodore J, ;2019;The Journal of neuroscience : the official journal of the Society for Neuroscience;39;6829-6847; 31253755
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Breeding at archiving centreMales were archived upon arrival at the archiving centre. No breeding was performed

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal tail movements / MGI
  • abnormal posture / MGI
  • impaired righting response / MGI
  • apnea / MGI
  • abnormal pain threshold / MGI
  • abnormal nervous system electrophysiology / MGI
  • impaired ability to fire action potentials / MGI
  • abnormal thermal nociception / MGI
  • abnormal mechanical nociception / MGI
  • catalepsy / MGI
  • hypoalgesia / MGI
  • abnormal single cell response / MGI
  • decreased thermal nociceptive threshold / MGI
  • abnormal brain wave pattern / MGI
  • behavior/neurological phenotype / MGI
  • abnormal action potential / MGI
  • hyperalgesia / MGI
  • abnormal RR interval / MGI
  • sinus bradycardia / MGI

Literature references

  • Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice.;Stirling L Caroline, Forlani Greta, Baker Mark D, Wood John N, Matthews Elizabeth A, Dickenson Anthony H, Nassar Mohammed A, ;2005;Pain;113;27-36; 15621361
  • Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling.;Megat Salim, Ray Pradipta R, Tavares-Ferreira Diana, Moy Jamie K, Sankaranarayanan Ishwarya, Wanghzou Andi, Fang Lou Tzu, Barragan-Iglesias Paulino, Campbell Zachary T, Dussor Gregory, Price Theodore J, ;2019;The Journal of neuroscience : the official journal of the Society for Neuroscience;39;6829-6847; 31253755
  • Ablation of sensory nerves favours melanoma progression.;Prazeres Pedro H D M, Leonel Caroline, Silva Walison N, Rocha Beatriz G S, Santos Gabryella S P, Costa Alinne C, Picoli Caroline C, Sena Isadora F G, Gonçalves William A, Vieira Mariana S, Costa Pedro A C, Campos Leda M C C, Lopes Miriam T P, Costa Marcos R, Resende Rodrigo R, Cunha Thiago M, Mintz Akiva, Birbrair Alexander, ;2020;Journal of cellular and molecular medicine;24;9574-9589; 32691511
  • Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression.;Costa Pedro A C, Silva Walison N, Prazeres Pedro H D M, Picoli Caroline C, Guardia Gabriela D A, Costa Alinne C, Oliveira Mariana A, Guimarães Pedro P G, Gonçalves Ricardo, Pinto Mauro C X, Amorim Jaime H, Azevedo Vasco A C, Resende Rodrigo R, Russo Remo C, Cunha Thiago M, Galante Pedro A F, Mintz Akiva, Birbrair Alexander, ;2021;Acta neuropathologica communications;9;183; 34784974
  • Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.;Maruyama Kenta, Takayama Yasunori, Kondo Takeshi, Ishibashi Ken-Ichi, Sahoo Bikash Ranjan, Kanemaru Hisashi, Kumagai Yutaro, Martino Mikaël M, Tanaka Hiroki, Ohno Naohito, Iwakura Yoichiro, Takemura Naoki, Tominaga Makoto, Akira Shizuo, ;2017;Cell reports;19;2730-2742; 28658621
  • Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.;Sugisawa Erika, Kondo Takeshi, Kumagai Yutaro, Kato Hiroki, Takayama Yasunori, Isohashi Kayako, Shimosegawa Eku, Takemura Naoki, Hayashi Yoshinori, Sasaki Takuya, Martino Mikaël M, Tominaga Makoto, Maruyama Kenta, ;2022;Cell reports;38;110462; 35263589
  • The Ablation of Sensory Neurons Expressing the Nav1.8 Sodium Channel Improves Glucose Homeostasis and Amplifies the GLP-1 Signaling in Obese Female Mice.;Romaní-Pérez Marina, Bullich-Vilarrubias Clara, López-Almela Inmaculada, Sanz Yolanda, ;2024;Molecular nutrition & food research;68;e2300474; 38038153
  • Nav1.8-expressing neurons control daily oscillations of food intake, body weight and gut microbiota in mice.;Bullich-Vilarrubias Clara, Romaní-Pérez Marina, López-Almela Inmaculada, Rubio Teresa, García Carlos J, Tomás-Barberán Francisco A, Sanz Yolanda, ;2024;Communications biology;7;219; 38388698
  • CGRP sensory neurons promote tissue healing via neutrophils and macrophages.;Lu Yen-Zhen, Nayer Bhavana, Singh Shailendra Kumar, Alshoubaki Yasmin K, Yuan Elle, Park Anthony J, Maruyama Kenta, Akira Shizuo, Martino Mikaël M, ;2024;Nature;628;604-611; 38538784

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