FVB/N-Tg(Rip-RASA1*)1Wid/Orl
| Status | Available to order |
| EMMA ID | EM:04569 |
| International strain name | FVB/N-Tg(Rip-RASA1*)1Wid/Orl |
| Alternative name | FVB/N-Tg(RIP::N)1Wid |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Rip-RASA1*)1Wid |
| Gene/Transgene symbol | Tg(Rip-RASA1*)1Wid |
Information from provider
| Provider | Christian Widmann |
| Provider affiliation | Physiology, Lausanne University |
| Genetic information | FVB/N-Tg(Rip-RASA1*)1Wid (Tg(RIP::N)1Wid) mice bear a transgene containing the rat insulin promoter followed by the cDNA encoding a caspase-resistant form of N-terminal fragment of human RasGAP. |
| Phenotypic information | FVB/N-Tg(RIP::N)1Wid mice are protected from experimentally-induced diabetes and display reduced in vivo beta-cell apoptosis. |
| Breeding history | The FVB/N-Tg(RIP::N)1Wid mouse line has been derived and is maintained in the FVB/N background. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous FVB/N, wild-type FVB/N |
| Breeding at archiving centre | transgenic males |
Literature references
- Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes.;Yang Jiang-Yan, Walicki Jöel, Jaccard Evrim, Dubuis Gilles, Bulat Natasa, Hornung Jean-Pierre, Thorens Bernard, Widmann Christian, ;2009;Diabetes;58;2596-606; 19696184