FVB/N-Tg(Rip-RASA1*)1Wid/Orl
| Status | Available to order |
| EMMA ID | EM:04569 |
| Citation information | RRID:IMSR_EM:04569 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB/N-Tg(Rip-RASA1*)1Wid/Orl |
| Alternative name | FVB/N-Tg(RIP::N)1Wid |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Rip-RASA1*)1Wid |
| Gene/Transgene symbol | Tg(Rip-RASA1*)1Wid |
Information from provider
| Provider | Christian Widmann |
| Provider affiliation | Physiology, Lausanne University |
| Genetic information | FVB/N-Tg(Rip-RASA1*)1Wid (Tg(RIP::N)1Wid) mice bear a transgene containing the rat insulin promoter followed by the cDNA encoding a caspase-resistant form of N-terminal fragment of human RasGAP. |
| Phenotypic information | FVB/N-Tg(RIP::N)1Wid mice are protected from experimentally-induced diabetes and display reduced in vivo beta-cell apoptosis. |
| Breeding history | The FVB/N-Tg(RIP::N)1Wid mouse line has been derived and is maintained in the FVB/N background. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous FVB/N males, wild-type FVB/N females |
| Breeding at archiving centre | transgenic males |
Literature references
- Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes.;Yang Jiang-Yan, Walicki Jöel, Jaccard Evrim, Dubuis Gilles, Bulat Natasa, Hornung Jean-Pierre, Thorens Bernard, Widmann Christian, ;2009;Diabetes;58;2596-606; 19696184