C57BL/6NTac-Ibsptm1e(EUCOMM)Wtsi/Cnrm

Status

Available to order

EMMA IDEM:04551
International strain nameC57BL/6NTac-Ibsptm1e(EUCOMM)Wtsi/Cnrm
Alternative nameEPD0197_1_C05
Strain typeTargeted Mutant Strains : Targeted Non-conditional
Allele/Transgene symbolIbsptm1e(EUCOMM)Wtsi
Gene/Transgene symbolIbsp
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0197_1_C05. For further details on the construction of this clone see the page at the IMPC portal. The targeted allele has lost the 3' loxP site. These mutations cannot be converted into conditional alleles. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
Animals used for archivingheterozygous C57BL/6NTac, wild-type C57BL/6NTac
Stage of embryos2-cell

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • large anterior fontanelle / MGI
  • malocclusion / MGI
  • abnormal trabecular bone morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal mandible morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal molar morphology / MGI
  • abnormal bone mineralization / MGI
  • abnormal bone remodeling / MGI
  • short femur / MGI
  • delayed intramembranous bone ossification / MGI
  • abnormal periodontal ligament morphology / MGI
  • abnormal osteoclast morphology / MGI
  • increased osteoclast cell number / MGI
  • decreased osteoclast cell number / MGI
  • abnormal osteoblast morphology / MGI
  • decreased osteoblast cell number / MGI
  • increased bone resorption / MGI
  • abnormal incisor morphology / MGI
  • craniofacial phenotype / MGI
  • skeleton phenotype / MGI
  • decreased trabecular bone thickness / MGI
  • delayed cranial suture closure / MGI
  • increased bone trabecula number / MGI
  • increased trabecular bone volume / MGI
  • abnormal osteoid morphology / MGI
  • increased osteoid thickness / MGI
  • abnormal tooth root development / MGI
  • decreased bone trabecular spacing / MGI
  • abnormal periodontium morphology / MGI
  • wide coronal suture / MGI
  • wide lambdoid suture / MGI
  • delayed fontanelle closure / MGI
  • abnormal cementum mineralization / MGI
  • alveolar process atrophy / MGI
  • abnormal molar root morphology / MGI
  • abnormal junctional epithelium morphology / MGI
  • abnormal tooth root resorption / MGI
  • misaligned incisors / MGI
  • abnormal acellular cementum morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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