B6.Cg-Tg(Cdh5-cre,-GFP)21Msri/Orl
| Status | Available to order |
| EMMA ID | EM:04549 |
| International strain name | B6.Cg-Tg(Cdh5-cre,-GFP)21Msri/Orl |
| Alternative name | VEC |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Cdh5-cre,-GFP)21Msri |
| Gene/Transgene symbol | Tg(Cdh5-cre,-GFP)21Msri |
Information from provider
| Provider | Michèle SOUYRI |
| Provider affiliation | Inserm |
| Genetic information | Introduction of cre recombinase under control of the cis-regulating elements (promoter+enhancer) of Cdh5 (VE-cadherin) gene. |
| Phenotypic information | No particular phenotype by itself. Needs to be mated with a floxed reporter line. Will allow to follow endothelial cell fate. |
| Breeding history | 5 to 6 backcrosses on C57BL/6. Inbred (to produce homozygous mice). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous 0 |
| Breeding at archiving centre | Transgenic males, it seems they are homozygous; crossed with wild-type C57BL/6J females. |
Literature references
- Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression.;Oberlin Estelle, El Hafny Bouchra, Petit-Cocault Laurence, Souyri Michèle, ;2010;The International journal of developmental biology;54;1165-73; 20711993