B6.Cg-Tg(Cdh5-cre,-GFP)21Msri/Orl
| Status | Available to order |
| EMMA ID | EM:04549 |
| Citation information | RRID:IMSR_EM:04549 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Cdh5-cre,-GFP)21Msri/Orl |
| Alternative name | VEC |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Cdh5-cre,-GFP)21Msri |
| Gene/Transgene symbol | Tg(Cdh5-cre,-GFP)21Msri |
Information from provider
| Provider | Michèle SOUYRI |
| Provider affiliation | Inserm |
| Genetic information | Introduction of cre recombinase under control of the cis-regulating elements (promoter+enhancer) of Cdh5 (VE-cadherin) gene. |
| Phenotypic information | No particular phenotype by itself. Needs to be mated with a floxed reporter line. Will allow to follow endothelial cell fate. |
| Breeding history | 5 to 6 backcrosses on C57BL/6. Inbred (to produce homozygous mice). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous males |
| Breeding at archiving centre | Transgenic males, it seems they are homozygous; crossed with wild-type C57BL/6J females. |
Literature references
- Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression.;Oberlin Estelle, El Hafny Bouchra, Petit-Cocault Laurence, Souyri Michèle, ;2010;The International journal of developmental biology;54;1165-73; 20711993