C57BL/6-Tg(CD19-cre/ERT2)1Jsv/Cnbc
| Status | Available to order |
| EMMA ID | EM:04499 |
| Citation information | RRID:IMSR_EM:04499 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(CD19-cre/ERT2)1Jsv/Cnbc |
| Alternative name | LC-1- hCD19CreERT2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CD19-cre/ERT2)1Jsv |
| Gene/Transgene symbol | Tg(CD19-cre/ERT2)1Jsv |
Information from provider
| Provider | Sjef Verbeek |
| Provider affiliation | Human Genetics, Leiden University Medical Center (LUMC) |
| Genetic information | BAC transgenic strain with 75 Kb LC-1 BAC with 6.3 Kb human CD19 promoter region driving CreERT2 (tamoxifen inducible). |
| Phenotypic information | B lymphocyte specific tamoxifen inducible Cre transgenic mouse strain. |
| Breeding history | Generated with Bruce4 ES cells (C57BL/6) and further backcrossed 3 generations to C57BL/6J. Currently maintained as homozygous by intercrossing. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Literature references
- Highly B lymphocyte-specific tamoxifen inducible transgene expression of CreER T2 by using the LC-1 locus BAC vector.;Boross Peter, Breukel Cor, van Loo Pieter Fokko, van der Kaa Jos, Claassens Jill W, Bujard Hermann, Schönig Kai, Verbeek J Sjef, ;2009;Genesis (New York, N.Y. : 2000);47;729-35; 19621440