B6Dnk;B6N-Hgstm1a(EUCOMM)Wtsi/Ieg

Status

Available to order

EMMA IDEM:04443
International strain nameB6Dnk;B6N-Hgstm1a(EUCOMM)Wtsi/Ieg
Alternative nameEPD0060_1_B12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolHgstm1a(EUCOMM)Wtsi
Gene/Transgene symbolHgs
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0060_1_B12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6Dnk, wild-type C57BL/6Dnk
Stage of embryos2-cell

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal behavior / IMPC
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • abnormal behavior / IMPC
MGI phenotypes (gene matching)
  • paralysis / MGI
  • abnormal medulla oblongata morphology / MGI
  • small cerebellum / MGI
  • Purkinje cell degeneration / MGI
  • abnormal brain development / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal CNS glial cell morphology / MGI
  • decreased spinal cord size / MGI
  • abnormal spinal nerve morphology / MGI
  • decreased body height / MGI
  • decreased body size / MGI
  • abnormal stationary movement / MGI
  • increased stereotypic behavior / MGI
  • abnormal posture / MGI
  • abnormal motor coordination/balance / MGI
  • impaired swimming / MGI
  • impaired balance / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • postnatal growth retardation / MGI
  • premature death / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • muscular atrophy / MGI
  • opisthotonus / MGI
  • axonal dystrophy / MGI
  • abnormal myelin sheath morphology / MGI
  • abnormal cerebellar cortex morphology / MGI
  • failure of initiation of embryo turning / MGI
  • cardia bifida / MGI
  • dilated allantois / MGI
  • abnormal vertebral spinous process morphology / MGI
  • abnormal vertebral column morphology / MGI
  • short vertebral body / MGI
  • cachexia / MGI
  • bradykinesia / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • hearing/vestibular/ear phenotype / MGI
  • abnormal axon morphology / MGI
  • jerky movement / MGI
  • abnormal cell physiology / MGI
  • thin cerebellar granule layer / MGI
  • embryonic lethality between implantation and somite formation / MGI
  • abnormal spinal cord white matter morphology / MGI
  • abnormal spinal cord grey matter morphology / MGI
  • decreased neuron number / MGI
  • decreased trabecular bone thickness / MGI
  • abnormal resting posture / MGI
  • failure of chorioallantoic fusion / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • absent foregut / MGI
  • decreased midbrain size / MGI
  • decreased hindbrain size / MGI
  • decreased corticospinal tract size / MGI
  • decreased pons size / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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