C57BL/6NTac-Ggt1^{tm1a(EUCOMM)Wtsi}/H

Status	Available to order
EMMA ID	EM:04434
International strain name	C57BL/6NTac-Ggt1^{tm1a(EUCOMM)Wtsi}/H
Alternative name	EPD0183_3_C02
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Ggt1^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Ggt1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from EUCOMM ES clone EPD0183_3_C02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	heterozygous C57BL/6NTac
Breeding at archiving centre	Chimeras were mated to C57BL/6NTac and maintained on this background thereafter.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Gamma-glutamyl transpeptidase deficiency / Orphanet_33573

MGI phenotypes (gene matching)

kyphosis / MGI
abnormal long bone hypertrophic chondrocyte zone / MGI
diluted coat color / MGI
hindlimb paralysis / MGI
abnormal ovarian folliculogenesis / MGI
absent corpus luteum / MGI
small testis / MGI
abnormal body weight / MGI
decreased body weight / MGI
decreased body size / MGI
abnormal lens morphology / MGI
cataract / MGI
hypoactivity / MGI
abnormal coat appearance / MGI
infertility / MGI
male infertility / MGI
female infertility / MGI
abnormal coat/hair pigmentation / MGI
abnormal glucose homeostasis / MGI
premature death / MGI
abnormal postnatal growth/weight/body size / MGI
abnormal skeleton development / MGI
disproportionate dwarf / MGI
oligozoospermia / MGI
short tibia / MGI
short femur / MGI
priapism / MGI
abnormal long bone epiphyseal plate proliferative zone / MGI
abnormal reproductive system development / MGI
decreased bone mass / MGI
small vertebrae / MGI
increased osteoclast cell number / MGI
skeleton phenotype / MGI
decreased thyroxine level / MGI
decreased long bone epiphyseal plate size / MGI
decreased spleen red pulp amount / MGI
nervous / MGI
nuclear cataracts / MGI
decreased glutathione level / MGI
glutathionuria / MGI
decreased circulating cysteine level / MGI
increased circulating glutathione level / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Reporterless null allele (tm1d allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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