C57BL/6NTac-Ggt1tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:04434
Citation informationRRID:IMSR_EM:04434 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Ggt1tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0183_3_C02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGgt1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolGgt1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0183_3_C02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6NTac males
Breeding at archiving centreChimeras were mated to C57BL/6NTac and maintained on this background thereafter.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • kyphosis / MGI
  • abnormal long bone hypertrophic chondrocyte zone / MGI
  • diluted coat color / MGI
  • hindlimb paralysis / MGI
  • abnormal ovarian folliculogenesis / MGI
  • absent corpus luteum / MGI
  • small testis / MGI
  • abnormal body weight / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal lens morphology / MGI
  • cataract / MGI
  • hypoactivity / MGI
  • abnormal coat appearance / MGI
  • infertility / MGI
  • male infertility / MGI
  • female infertility / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal glucose homeostasis / MGI
  • premature death / MGI
  • abnormal postnatal growth/weight/body size / MGI
  • abnormal skeleton development / MGI
  • disproportionate dwarf / MGI
  • oligozoospermia / MGI
  • short tibia / MGI
  • short femur / MGI
  • priapism / MGI
  • abnormal long bone epiphyseal plate proliferative zone / MGI
  • abnormal reproductive system development / MGI
  • decreased bone mass / MGI
  • small vertebrae / MGI
  • increased osteoclast cell number / MGI
  • skeleton phenotype / MGI
  • decreased thyroxine level / MGI
  • decreased long bone epiphyseal plate size / MGI
  • decreased spleen red pulp amount / MGI
  • nervous / MGI
  • nuclear cataracts / MGI
  • decreased glutathione level / MGI
  • glutathionuria / MGI
  • decreased circulating cysteine level / MGI
  • increased circulating glutathione level / MGI

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