IMPC phenotypes (allele matching)
- preweaning lethality, complete penetrance / IMPC
B6Dnk;B6N-Ercc2tm1a(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:04416 |
| International strain name | B6Dnk;B6N-Ercc2tm1a(EUCOMM)Wtsi/H |
| Alternative name | EPD0105_4_A10 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Ercc2tm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Ercc2 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0105_4_A10. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6Dnk |
| Breeding at archiving centre | Chimeras were mated to C57BL/6Dnk and maintained on this background thereafter. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- COFS syndrome / Orphanet_1466
- Xeroderma pigmentosum-Cockayne syndrome complex / Orphanet_220295
- Trichothiodystrophy / Orphanet_33364
- Xeroderma pigmentosum / Orphanet_910
IMPC phenotypes (gene matching)
- preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- osteoporosis / MGI
- kyphosis / MGI
- decreased hematocrit / MGI
- abnormal coat/ hair morphology / MGI
- abnormal hair follicle morphology / MGI
- enlarged hair follicles / MGI
- alopecia / MGI
- sparse hair / MGI
- abnormal sebaceous gland morphology / MGI
- enlarged sebaceous gland / MGI
- enlarged spleen / MGI
- tremors / MGI
- abnormal testis morphology / MGI
- reddish skin / MGI
- scaly skin / MGI
- thick skin / MGI
- skin photosensitivity / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- hyperkeratosis / MGI
- decreased body size / MGI
- microphthalmia / MGI
- abnormal lens morphology / MGI
- cataract / MGI
- small lens / MGI
- corneal opacity / MGI
- decreased exploration in new environment / MGI
- limb grasping / MGI
- anemia / MGI
- abnormal hemoglobin / MGI
- postnatal growth retardation / MGI
- acanthosis / MGI
- reduced female fertility / MGI
- female infertility / MGI
- abnormal ovulation / MGI
- neoplasm / MGI
- increased incidence of induced tumors / MGI
- premature death / MGI
- disproportionate dwarf / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- white spotting / MGI
- astrocytosis / MGI
- nervous system phenotype / MGI
- premature aging / MGI
- abnormal hair cuticle / MGI
- brittle hair / MGI
- greasy coat / MGI
- increased incidence of tumors by chemical induction / MGI
- increased incidence of tumors by UV-induction / MGI
- cachexia / MGI
- abnormal circulating amino acid level / MGI
- growth/size/body region phenotype / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal skeleton morphology / MGI
- abnormal cell physiology / MGI
- abnormal DNA repair / MGI
- increased cellular sensitivity to ultraviolet irradiation / MGI
- decreased cellular sensitivity to ultraviolet irradiation / MGI
- microgliosis / MGI
- abnormal fat cell morphology / MGI
- decreased total body fat amount / MGI
- rough coat / MGI
- focal dorsal hair loss / MGI
- nuclear cataracts / MGI
- increased skin tumor incidence / MGI
- decreased tumor latency / MGI
- mortality/aging / MGI
- integument phenotype / MGI
- embryonic lethality before implantation, complete penetrance / MGI
- vacuolated lens / MGI
- abnormal response to radiation / MGI