FVB-Tg(tetO-Hgf,-EGFP)24Tcre/Cnrm
| Status | Available to order |
| EMMA ID | EM:04364 |
| International strain name | FVB-Tg(tetO-Hgf,-EGFP)24Tcre/Cnrm |
| Alternative name | Hgf-TetO-GFP |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-Hgf,-EGFP)24Tcre |
| Gene/Transgene symbol | Tg(tetO-Hgf,-EGFP)24Tcre |
Information from provider
| Provider | Tiziana Crepaldi |
| Provider affiliation | Anatomy Pharmacology and Forensic Medicine, University of Turin |
| Genetic information | In order to obtain tetracycline controlled expression of Hgf, the murine Hgf cDNA was cloned into the pBI-eGFP vector (Clontech) to generate the bidirectional Hgf-TetO-GFP responder. Gene expression was induced in the heart by crossing the Hgf-TetO-GFP transgenic line with mice which carry a transgene consisting of the tTA driven by cardiac alpha-MHC promoter. The GFP gene facilitates detection of responder transgene on whole organ as well as in tissue sections. |
| Phenotypic information | No phenotype was observed in single transgenic mice. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- A mouse model for spatial and temporal expression of HGF in the heart.;Riess Ilan, Sala Valentina, Leo Christian, Demaria Marco, Gatti Stefano, Gallo Simona, Fitou Amandine, Boero Ombretta, Levi Renzo, Cuccovillo Ivan, Molla Fabiola, De Angelis Noeleen, Staszewsky Lidia, Latini Roberto, Crepaldi Tiziana, ;2011;Transgenic research;20;1203-16; 21360304
- Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes.;Morena Deborah, Maestro Nicola, Bersani Francesca, Forni Paolo Emanuele, Lingua Marcello Francesco, Foglizzo Valentina, Šćepanović Petar, Miretti Silvia, Morotti Alessandro, Shern Jack F, Khan Javed, Ala Ugo, Provero Paolo, Sala Valentina, Crepaldi Tiziana, Gasparini Patrizia, Casanova Michela, Ferrari Andrea, Sozzi Gabriella, Chiarle Roberto, Ponzetto Carola, Taulli Riccardo, ;2016;eLife;5;; 26987019