STOCK Myo7a4494SB/NihrH

Status

Available to order

EMMA IDEM:00436
International strain nameSTOCK Myo7a4494SB/NihrH
Alternative nameMyo7a
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolMyo7a4494SB
Gene/Transgene symbolMyo7a

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Phenotypic informationMice homozygous for this mutation exhibit almost constant circling behaviour and show no Preyer reflex. Heterozygotes and wild-types are indistinguishable.
References
  • Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.;Hasson T, Walsh J, Cable J, Mooseker M S, Brown S D, Steel K P, ;1997;Cell motility and the cytoskeleton;37;127-38; 9186010

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased lean body mass / IMPC
  • abnormal locomotor activation / IMPC
  • trunk curl / IMPC
  • persistence of hyaloid vascular system / IMPC
  • absent pinna reflex / IMPC
  • increased lean body mass / IMPC
  • impaired righting response / IMPC
  • increased blood urea nitrogen level / IMPC
  • increased total body fat amount / IMPC
  • decreased body weight / IMPC
  • increased thermal nociceptive threshold / IMPC
  • abnormal bone mineralization / IMPC
  • increased bone mineral content / IMPC
  • decreased body length / IMPC
  • abnormal behavior / IMPC
  • decreased bone mineral density / IMPC
  • increased circulating sodium level / IMPC
  • stereotypic behavior / IMPC
MGI phenotypes (allele matching)
  • abnormal hair cell morphology / MGI
  • abnormal hearing physiology / MGI
MGI phenotypes (gene matching)
  • abnormal inner ear vestibule morphology / MGI
  • abnormal organ of Corti morphology / MGI
  • abnormal hair cell morphology / MGI
  • abnormal head movements / MGI
  • abnormal retinal rod cell morphology / MGI
  • pigmentation phenotype / MGI
  • decreased body size / MGI
  • increased anxiety-related response / MGI
  • circling / MGI
  • hyperactivity / MGI
  • abnormal gait / MGI
  • head bobbing / MGI
  • decreased startle reflex / MGI
  • trunk curl / MGI
  • impaired swimming / MGI
  • impaired balance / MGI
  • reduced male fertility / MGI
  • male infertility / MGI
  • abnormal hearing physiology / MGI
  • deafness / MGI
  • abnormal parental behavior / MGI
  • gliosis / MGI
  • abnormal cochlear hair cell morphology / MGI
  • head shaking / MGI
  • cochlear ganglion degeneration / MGI
  • no phenotypic analysis / MGI
  • straub tail / MGI
  • abnormal ear physiology / MGI
  • vestibular saccular macula degeneration / MGI
  • cochlear hair cell degeneration / MGI
  • stria vascularis degeneration / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • decreased cochlear outer hair cell number / MGI
  • cochlear outer hair cell degeneration / MGI
  • absent cochlear microphonics / MGI
  • abnormal cochlear nerve compound action potential / MGI
  • short cochlear outer hair cells / MGI
  • abnormal orientation of outer hair cell stereociliary bundles / MGI
  • abnormal orientation of inner hair cell stereociliary bundles / MGI
  • abnormal vestibular hair cell stereociliary bundle morphology / MGI
  • decreased vestibular hair cell stereocilia number / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • abnormal orientation of cochlear hair cell stereociliary bundles / MGI
  • short cochlear hair cell stereocilia / MGI
  • abnormal outer hair cell stereociliary bundle morphology / MGI
  • decreased outer hair cell stereocilia number / MGI
  • abnormal inner hair cell stereociliary bundle morphology / MGI
  • fused inner hair cell stereocilia / MGI
  • decreased inner hair cell stereocilia number / MGI
  • abnormal cochlear hair cell inter-stereocilial links morphology / MGI
  • absent cochlear hair bundle ankle links / MGI
  • abnormal cochlear basement membrane morphology / MGI
  • abnormal cochlear OHC efferent innervation pattern / MGI
  • absent distortion product otoacoustic emissions / MGI
  • increased susceptibility to age-related hearing loss / MGI
  • increased cochlear nerve compound action potential / MGI
  • absent linear vestibular evoked potential / MGI
  • abnormal behavior / MGI
  • head tilt / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • head tossing / MGI
  • hearing/vestibular/ear phenotype / MGI
  • jerky movement / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • absent startle reflex / MGI
  • abnormal auditory summating potential / MGI
  • vestibular ganglion hypoplasia / MGI
  • retinal rod cell degeneration / MGI
  • slow postnatal weight gain / MGI
  • retropulsion / MGI
  • increased food intake / MGI
  • increased fluid intake / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Literature references

  • Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.;Hasson T, Walsh J, Cable J, Mooseker M S, Brown S D, Steel K P, ;1997;Cell motility and the cytoskeleton;37;127-38; 9186010

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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