FVB;129P2-Cdkn2atm1.1Brn/Cnrm
Status | Available to order |
EMMA ID | EM:00435 |
International strain name | FVB;129P2-Cdkn2atm1.1Brn/Cnrm |
Alternative name | P16B |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Cdkn2atm1.1Brn, |
Gene/Transgene symbol | Cdkn2a |
Information from provider
Provider | Anton Berns |
Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
Genetic information | Point mutation in exon 2 (p16Ink4a open reading frame) of Cdkn2a gene; hom. rec. in ES cells |
Phenotypic information | p16Ink4a-specific mutant with expression of functional p19Arf; shows no obvious phenotype |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.;Krimpenfort P, Quon K C, Mooi W J, Loonstra A, Berns A, ;2001;Nature;413;83-6; 11544530
- Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma.;Vengoji Raghupathy, Atri Pranita, Macha Muzafar A, Seshacharyulu Parthasarathy, Perumal Naveenkumar, Mallya Kavita, Liu Yutong, Smith Lynette M, Rachagani Satyanarayana, Mahapatra Sidharth, Ponnusamy Moorthy P, Jain Maneesh, Batra Surinder K, Shonka Nicole, ;2021;Journal of experimental & clinical cancer research : CR;40;335; 34696786
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