IMPC phenotypes (gene matching)
FVB;129P2-Cdkn2atm1.1Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:00435 |
| International strain name | FVB;129P2-Cdkn2atm1.1Brn/Cnrm |
| Alternative name | P16B |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Cdkn2atm1.1Brn |
| Gene/Transgene symbol | Cdkn2a |
Information from provider
| Provider | Anton Berns |
| Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
| Genetic information | Point mutation in exon 2 (p16Ink4a open reading frame) of Cdkn2a gene; hom. rec. in ES cells |
| Phenotypic information | p16Ink4a-specific mutant with expression of functional p19Arf; shows no obvious phenotype |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- extramedullary hematopoiesis / MGI
- abnormal spleen morphology / MGI
- thymus hyperplasia / MGI
- hindlimb paralysis / MGI
- abnormal retinal photoreceptor morphology / MGI
- increased metastatic potential / MGI
- microphthalmia / MGI
- abnormal lens morphology / MGI
- cataract / MGI
- abnormal retina morphology / MGI
- male infertility / MGI
- blindness / MGI
- neoplasm / MGI
- increased papilloma incidence / MGI
- abnormal tumor incidence / MGI
- increased tumor incidence / MGI
- increased B cell derived lymphoma incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased sarcoma incidence / MGI
- increased fibrohistocytoma incidence / MGI
- increased carcinoma incidence / MGI
- seizures / MGI
- premature death / MGI
- abnormal eye morphology / MGI
- abnormal spleen red pulp morphology / MGI
- abnormal sperm number / MGI
- oligozoospermia / MGI
- no phenotypic analysis / MGI
- abnormal cell cycle / MGI
- retinal detachment / MGI
- testicular atrophy / MGI
- abnormal lens capsule morphology / MGI
- abnormal keratinocyte physiology / MGI
- increased hemangiosarcoma incidence / MGI
- increased tumor growth/size / MGI
- abnormal retinal inner nuclear layer morphology / MGI
- increased osteosarcoma incidence / MGI
- increased squamous cell carcinoma incidence / MGI
- increased incidence of tumors by chemical induction / MGI
- increased incidence of tumors by ionizing radiation induction / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased testis weight / MGI
- decreased testis weight / MGI
- increased thymus weight / MGI
- increased double-positive T cell number / MGI
- abnormal posterior eye segment morphology / MGI
- abnormal retinal ganglion layer morphology / MGI
- reproductive system phenotype / MGI
- vision/eye phenotype / MGI
- abnormal skin physiology / MGI
- abnormal lens development / MGI
- abnormal cell physiology / MGI
- abnormal retinal neuronal layer morphology / MGI
- binocular blindness / MGI
- abnormal spermatocyte morphology / MGI
- delayed cellular replicative senescence / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased spleen white pulp amount / MGI
- increased lung carcinoma incidence / MGI
- increased brain tumor incidence / MGI
- increased small lymphocytic lymphoma incidence / MGI
- increased histiocytic sarcoma incidence / MGI
- increased splenocyte proliferation / MGI
- increased gastrointestinal stromal tumor incidence / MGI
- primary vitreous hyperplasia / MGI
- increased melanoma incidence / MGI
- increased cutaneous melanoma incidence / MGI
- increased acute lymphoblastic leukemia incidence / MGI
- increased fibrosarcoma incidence / MGI
- persistent hyperplastic primary vitreous / MGI
- increased fibroblast proliferation / MGI
- increased lymphoma incidence / MGI
Literature references
- Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.;Krimpenfort P, Quon K C, Mooi W J, Loonstra A, Berns A, ;2001;Nature;413;83-6; 11544530
- Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma.;Vengoji Raghupathy, Atri Pranita, Macha Muzafar A, Seshacharyulu Parthasarathy, Perumal Naveenkumar, Mallya Kavita, Liu Yutong, Smith Lynette M, Rachagani Satyanarayana, Mahapatra Sidharth, Ponnusamy Moorthy P, Jain Maneesh, Batra Surinder K, Shonka Nicole, ;2021;Journal of experimental & clinical cancer research : CR;40;335; 34696786