FVB;129P2-Rb1tm1Brn/Cnrm

Status

Available to order

EMMA IDEM:00434
Citation informationRRID:IMSR_EM:00434 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameFVB;129P2-Rb1tm1Brn/Cnrm
Alternative nameRbFR
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolRb1tm1Brn
Gene/Transgene symbolRb1

Information from provider

ProviderAnton Berns
Provider affiliationResearch - Animal Facility, The Netherlands Cancer Institute
Genetic informationTwo frt sequences were inserted into the introns surrounding exon 19 of the Rb1 gene. Using a two step hit-and-run gene targeting strategy these frt sites were introduced into the mouse genome. An Hprt resistance gene was included that allowed both positive and negative selection in the HM-1, Hprt-deficient ES cell line.
Phenotypic informationConditional Rb1 (RbFR) mutant; no phenotype.
References
  • Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.;Vooijs M, van der Valk M, te Riele H, Berns A, ;1998;Oncogene;17;1-12; 9671308

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • kyphosis / MGI
  • abnormal cartilage morphology / MGI
  • abnormal erythropoiesis / MGI
  • abnormal cell proliferation / MGI
  • increased cell proliferation / MGI
  • abnormal liver morphology / MGI
  • liver hypoplasia / MGI
  • small liver / MGI
  • enlarged liver sinusoidal spaces / MGI
  • decreased hepatocyte number / MGI
  • abnormal hepatocyte morphology / MGI
  • mammary gland hyperplasia / MGI
  • abnormal neuroendocrine gland morphology / MGI
  • decreased brain size / MGI
  • abnormal frontal lobe morphology / MGI
  • abnormal third ventricle morphology / MGI
  • abnormal fourth ventricle morphology / MGI
  • dilated fourth ventricle / MGI
  • abnormal Purkinje cell morphology / MGI
  • ectopic Purkinje cell / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • small dorsal root ganglion / MGI
  • abnormal trigeminal ganglion morphology / MGI
  • obese / MGI
  • increased metastatic potential / MGI
  • cataract / MGI
  • abnormal pilomotor reflex / MGI
  • hunched posture / MGI
  • anemia / MGI
  • abnormal myelopoiesis / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal embryo development / MGI
  • decreased embryo size / MGI
  • abnormal placenta labyrinth morphology / MGI
  • pale yolk sac / MGI
  • edema / MGI
  • skin edema / MGI
  • pericardial edema / MGI
  • mammary gland duct hyperplasia / MGI
  • respiratory distress / MGI
  • neoplasm / MGI
  • preneoplasia / MGI
  • increased tumor incidence / MGI
  • increased pituitary adenoma incidence / MGI
  • increased pheochromocytoma incidence / MGI
  • premature death / MGI
  • abnormal definitive hematopoiesis / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • neurodegeneration / MGI
  • abnormal macrophage morphology / MGI
  • abnormal erythrocyte morphology / MGI
  • low mean erythrocyte cell number / MGI
  • abnormal lens fiber morphology / MGI
  • decreased erythrocyte cell number / MGI
  • no phenotypic analysis / MGI
  • abnormal cell cycle / MGI
  • increased neuron apoptosis / MGI
  • nervous system phenotype / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal chromosome morphology / MGI
  • pallor / MGI
  • abnormal milk ejection / MGI
  • embryonic growth retardation / MGI
  • aneuploidy / MGI
  • abnormal cell cycle checkpoint function / MGI
  • abnormal mitosis / MGI
  • decreased fetal size / MGI
  • abnormal placental transport / MGI
  • hypoxia / MGI
  • abnormal cell differentiation / MGI
  • cachexia / MGI
  • lethargy / MGI
  • digestive/alimentary phenotype / MGI
  • cellular phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal lens development / MGI
  • increased apoptosis / MGI
  • decreased apoptosis / MGI
  • abnormal retinal apoptosis / MGI
  • increased body mass index / MGI
  • thin cerebellar granule layer / MGI
  • increased lung tumor incidence / MGI
  • abnormal macrophage differentiation / MGI
  • increased megakaryocyte cell number / MGI
  • enlarged fourth ventricle / MGI
  • increased lens fiber apoptosis / MGI
  • increased brain tumor incidence / MGI
  • increased nucleated erythrocyte cell number / MGI
  • skeletal muscle atrophy / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • abnormal neuron differentiation / MGI
  • increased thyroid tumor incidence / MGI
  • increased pituitary gland tumor incidence / MGI
  • increased thyroid C-cell carcinoma incidence / MGI
  • increased pituitary adenohypophysis tumor incidence / MGI
  • increased pituitary melanotroph tumor incidence / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • increased fibroblast proliferation / MGI
  • decreased retinal apoptosis / MGI
  • flat forehead / MGI

Literature references

  • Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.;Vooijs M, van der Valk M, te Riele H, Berns A, ;1998;Oncogene;17;1-12; 9671308

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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