- kyphosis / MGI
- abnormal cartilage morphology / MGI
- abnormal erythropoiesis / MGI
- abnormal cell proliferation / MGI
- increased cell proliferation / MGI
- abnormal liver morphology / MGI
- liver hypoplasia / MGI
- small liver / MGI
- enlarged liver sinusoidal spaces / MGI
- decreased hepatocyte number / MGI
- abnormal hepatocyte morphology / MGI
- mammary gland hyperplasia / MGI
- abnormal neuroendocrine gland morphology / MGI
- decreased brain size / MGI
- abnormal frontal lobe morphology / MGI
- abnormal third ventricle morphology / MGI
- abnormal fourth ventricle morphology / MGI
- dilated fourth ventricle / MGI
- abnormal Purkinje cell morphology / MGI
- ectopic Purkinje cell / MGI
- abnormal dorsal root ganglion morphology / MGI
- small dorsal root ganglion / MGI
- abnormal trigeminal ganglion morphology / MGI
- obese / MGI
- increased metastatic potential / MGI
- cataract / MGI
- abnormal pilomotor reflex / MGI
- hunched posture / MGI
- anemia / MGI
- abnormal myelopoiesis / MGI
- abnormal blood vessel morphology / MGI
- abnormal embryo development / MGI
- decreased embryo size / MGI
- abnormal placenta labyrinth morphology / MGI
- pale yolk sac / MGI
- edema / MGI
- skin edema / MGI
- pericardial edema / MGI
- mammary gland duct hyperplasia / MGI
- respiratory distress / MGI
- neoplasm / MGI
- preneoplasia / MGI
- increased tumor incidence / MGI
- increased pituitary adenoma incidence / MGI
- increased pheochromocytoma incidence / MGI
- premature death / MGI
- abnormal definitive hematopoiesis / MGI
- abnormal brain morphology / MGI
- no abnormal phenotype detected / MGI
- neurodegeneration / MGI
- abnormal macrophage morphology / MGI
- abnormal erythrocyte morphology / MGI
- low mean erythrocyte cell number / MGI
- abnormal lens fiber morphology / MGI
- decreased erythrocyte cell number / MGI
- no phenotypic analysis / MGI
- abnormal cell cycle / MGI
- increased neuron apoptosis / MGI
- nervous system phenotype / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal chromosome morphology / MGI
- pallor / MGI
- abnormal milk ejection / MGI
- embryonic growth retardation / MGI
- aneuploidy / MGI
- abnormal cell cycle checkpoint function / MGI
- abnormal mitosis / MGI
- decreased fetal size / MGI
- abnormal placental transport / MGI
- hypoxia / MGI
- abnormal cell differentiation / MGI
- cachexia / MGI
- lethargy / MGI
- digestive/alimentary phenotype / MGI
- cellular phenotype / MGI
- vision/eye phenotype / MGI
- abnormal lens development / MGI
- increased apoptosis / MGI
- decreased apoptosis / MGI
- abnormal retinal apoptosis / MGI
- increased body mass index / MGI
- thin cerebellar granule layer / MGI
- increased lung tumor incidence / MGI
- abnormal macrophage differentiation / MGI
- increased megakaryocyte cell number / MGI
- enlarged fourth ventricle / MGI
- increased lens fiber apoptosis / MGI
- increased brain tumor incidence / MGI
- increased nucleated erythrocyte cell number / MGI
- skeletal muscle atrophy / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- abnormal neuron differentiation / MGI
- increased thyroid tumor incidence / MGI
- increased pituitary gland tumor incidence / MGI
- increased thyroid C-cell carcinoma incidence / MGI
- increased pituitary adenohypophysis tumor incidence / MGI
- increased pituitary melanotroph tumor incidence / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- increased fibroblast proliferation / MGI
- decreased retinal apoptosis / MGI
- flat forehead / MGI
FVB;129P2-Rb1tm2Brn/Cnrm
Status | Available to order |
EMMA ID | EM:00433 |
International strain name | FVB;129P2-Rb1tm2Brn/Cnrm |
Alternative name | RbF |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Rb1tm2Brn |
Gene/Transgene symbol | Rb1 |
Information from provider
Provider | Anton Berns |
Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
Genetic information | Insertion of loxP sequences into the introns surrounding exon 19 of the Rb1 gene. |
Phenotypic information | Conditional Rb1 knock-out; no phenotype. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Small cell lung cancer / Orphanet_70573
- Non-hereditary retinoblastoma / Orphanet_357034
- Hereditary retinoblastoma / Orphanet_357027
MGI phenotypes (gene matching)
Literature references
- Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.;Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A, ;2000;Genes & development;14;994-1004; 10783170
Information on how we integrate external resources can be found here
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