MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6;129S2-Synatm1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:04323 |
| Citation information | RRID:IMSR_EM:04323 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S2-Synatm1Ics/Ics |
| Alternative name | Syncytin-A conditional KO |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Synatm1Ics |
| Gene/Transgene symbol | Syna |
Information from provider
| Provider | Thierry Heidmann |
| Provider affiliation | U805 INSERM, Institut Gustave Roussy |
| Genetic information | In the targeting vector, the syncytin-A ORF and surrounding sequences were generated from 129/Sv mouse DNA by PCR. The targeted allele contains the unique syncytin-A ORF flanked by loxP recombination sites allowing its conditional excision. |
| Phenotypic information | Mice with conditional alleles: no obvious phenotypic defects. Mice with syncytin-A knock-out allele (after cre recombinase-mediated excision of syncytin-A ORF): embryonic death of homozygous null embryos at mid gestation. Impaired placental syncytial formation and trophoblast differentiation. |
| Breeding history | Strain is maintained by crossing heterozygous mutants with 129/Sv mice; approx. 4-5 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
| Animals used for archiving | heterozygous C57BL/6;129 males, wild-type C57BL/6J females |
| Stage of embryos | 8-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal placenta labyrinth morphology / MGI
- no phenotypic analysis / MGI
- abnormal vitelline vasculature morphology / MGI
- pallor / MGI
- embryonic growth retardation / MGI
- abnormal placental transport / MGI
- increased trophoblast giant cell number / MGI
- decreased embryo weight / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
Literature references
- Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene.;Dupressoir Anne, Vernochet Cécile, Bawa Olivia, Harper Francis, Pierron Gérard, Opolon Paule, Heidmann Thierry, ;2009;Proceedings of the National Academy of Sciences of the United States of America;106;12127-32; 19564597