MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6;129S2-Synatm1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:04323 |
| International strain name | B6;129S2-Synatm1Ics/Ics |
| Alternative name | Syncytin-A conditional KO |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Synatm1Ics, |
| Gene/Transgene symbol | Syna |
Information from provider
| Provider | Thierry Heidmann |
| Provider affiliation | U805 INSERM, Institut Gustave Roussy |
| Genetic information | In the targeting vector, the syncytin-A ORF and surrounding sequences were generated from 129/Sv mouse DNA by PCR. The targeted allele contains the unique syncytin-A ORF flanked by loxP recombination sites allowing its conditional excision. |
| Phenotypic information | Mice with conditional alleles: no obvious phenotypic defects. Mice with syncytin-A knock-out allele (after cre recombinase-mediated excision of syncytin-A ORF): embryonic death of homozygous null embryos at mid gestation. Impaired placental syncytial formation and trophoblast differentiation. |
| Breeding history | Strain is maintained by crossing heterozygous mutants with 129/Sv mice; approx. 4-5 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
| Animals used for archiving | heterozygous C57BL/6;129, wild-type C57BL/6J |
| Stage of embryos | 8-cell |
Disease and phenotype information
Literature references
- Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene.;Dupressoir Anne, Vernochet Cécile, Bawa Olivia, Harper Francis, Pierron Gérard, Opolon Paule, Heidmann Thierry, ;2009;Proceedings of the National Academy of Sciences of the United States of America;106;12127-32; 19564597