B6.129-Cd81tm1Lvy/Orl

Status

Available to order

EMMA IDEM:04305
Citation informationRRID:IMSR_EM:04305 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129-Cd81tm1Lvy/Orl
Alternative nameB6-backcrossed Cd81 knockout
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCd81tm1Lvy
Gene/Transgene symbolCd81

Information from provider

ProviderShoshana Levy
Provider affiliationDepartment of Bioengineering, Stanford University
Genetic informationCd81 knockout mice.
Phenotypic informationFemale infertility, resistance to infection by Plasmodium sporozoites, impairment in the immune and nervous systems.
Breeding historyFemale infertility of Cd81 mice was manifested after the 4th backcross to a homozygous background (C57BL/6 and BALB/c). The mice have been backcrossed onto the C57BL/6 background for at least 8 generation.
References
  • Normal lymphocyte development but delayed humoral immune response in CD81-null mice.;Maecker H T, Levy S, ;1997;The Journal of experimental medicine;185;1505-10; 9126932
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J males, wild-type C57BL/6J females
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • thickened cerebral cortex / MGI
  • increased brain weight / MGI
  • abnormal T-helper 2 physiology / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • increased hippocampus volume / MGI
  • nervous system phenotype / MGI
  • decreased IgG level / MGI
  • abnormal B cell morphology / MGI
  • decreased susceptibility to parasitic infection / MGI
  • decreased IgG1 level / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal CNS glial cell morphology / MGI
  • abnormal neuron morphology / MGI
  • abnormal hippocampus CA1 region morphology / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • increased astrocyte number / MGI
  • abnormal microglial cell morphology / MGI
  • abnormal corpus callosum morphology / MGI
MGI phenotypes (gene matching)
  • abnormal microglial cell morphology / MGI
  • abnormal immune system cell morphology / MGI
  • abnormal corpus callosum morphology / MGI
  • thickened cerebral cortex / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal CNS glial cell morphology / MGI
  • hypoactivity / MGI
  • decreased IgG level / MGI
  • increased dopamine level / MGI
  • abnormal B cell differentiation / MGI
  • increased brain weight / MGI
  • abnormal macrophage physiology / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • abnormal neuron morphology / MGI
  • nervous system phenotype / MGI
  • abnormal nucleus accumbens morphology / MGI
  • abnormal B cell morphology / MGI
  • decreased B-1 B cell number / MGI
  • decreased susceptibility to parasitic infection / MGI
  • decreased B cell proliferation / MGI
  • abnormal T cell proliferation / MGI
  • increased B cell proliferation / MGI
  • abnormal T-helper 2 physiology / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • decreased B-1a cell number / MGI
  • abnormal hippocampus CA1 region morphology / MGI
  • decreased IgG1 level / MGI
  • increased IgG3 level / MGI
  • impaired behavioral response to cocaine / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • increased astrocyte number / MGI
  • increased hippocampus volume / MGI

Literature references

  • Normal lymphocyte development but delayed humoral immune response in CD81-null mice.;Maecker H T, Levy S, ;1997;The Journal of experimental medicine;185;1505-10; 9126932

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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