STOCK Myo7a816SB/NihrH

Status

Available to order

EMMA IDEM:00428
International strain nameSTOCK Myo7a816SB/NihrH
Alternative nameMyo7a
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolMyo7a816SB
Gene/Transgene symbolMyo7a

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mutation can also be identified by genotyping. See Self et al. (1998) Development, vol 125, 557-566.
Phenotypic informationMice homozygous for this mutation exhibit almost constant circling behaviour and show no Preyer reflex. Heterozygotes and wild-types are indistinguishable.
References
  • Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells.;Self T, Mahony M, Fleming J, Walsh J, Brown S D, Steel K P, ;1998;Development (Cambridge, England);125;557-66; 9435277
  • Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.;Hasson T, Walsh J, Cable J, Mooseker M S, Brown S D, Steel K P, ;1997;Cell motility and the cytoskeleton;37;127-38; 9186010

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased lean body mass / IMPC
  • abnormal locomotor activation / IMPC
  • trunk curl / IMPC
  • persistence of hyaloid vascular system / IMPC
  • absent pinna reflex / IMPC
  • increased lean body mass / IMPC
  • impaired righting response / IMPC
  • increased blood urea nitrogen level / IMPC
  • increased total body fat amount / IMPC
  • decreased body weight / IMPC
  • increased thermal nociceptive threshold / IMPC
  • abnormal bone mineralization / IMPC
  • increased bone mineral content / IMPC
  • decreased body length / IMPC
  • abnormal behavior / IMPC
  • decreased bone mineral density / IMPC
  • increased circulating sodium level / IMPC
  • stereotypic behavior / IMPC
MGI phenotypes (allele matching)
  • abnormal hair cell morphology / MGI
  • abnormal hearing physiology / MGI
  • absent cochlear microphonics / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • abnormal orientation of cochlear hair cell stereociliary bundles / MGI
  • abnormal auditory summating potential / MGI
MGI phenotypes (gene matching)
  • abnormal inner ear vestibule morphology / MGI
  • abnormal organ of Corti morphology / MGI
  • abnormal hair cell morphology / MGI
  • abnormal head movements / MGI
  • abnormal retinal rod cell morphology / MGI
  • pigmentation phenotype / MGI
  • decreased body size / MGI
  • increased anxiety-related response / MGI
  • circling / MGI
  • hyperactivity / MGI
  • abnormal gait / MGI
  • head bobbing / MGI
  • decreased startle reflex / MGI
  • trunk curl / MGI
  • impaired swimming / MGI
  • impaired balance / MGI
  • reduced male fertility / MGI
  • male infertility / MGI
  • abnormal hearing physiology / MGI
  • deafness / MGI
  • abnormal parental behavior / MGI
  • gliosis / MGI
  • abnormal cochlear hair cell morphology / MGI
  • head shaking / MGI
  • cochlear ganglion degeneration / MGI
  • no phenotypic analysis / MGI
  • straub tail / MGI
  • abnormal ear physiology / MGI
  • vestibular saccular macula degeneration / MGI
  • cochlear hair cell degeneration / MGI
  • stria vascularis degeneration / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • decreased cochlear outer hair cell number / MGI
  • cochlear outer hair cell degeneration / MGI
  • absent cochlear microphonics / MGI
  • abnormal cochlear nerve compound action potential / MGI
  • short cochlear outer hair cells / MGI
  • abnormal orientation of outer hair cell stereociliary bundles / MGI
  • abnormal orientation of inner hair cell stereociliary bundles / MGI
  • abnormal vestibular hair cell stereociliary bundle morphology / MGI
  • decreased vestibular hair cell stereocilia number / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • abnormal orientation of cochlear hair cell stereociliary bundles / MGI
  • short cochlear hair cell stereocilia / MGI
  • abnormal outer hair cell stereociliary bundle morphology / MGI
  • decreased outer hair cell stereocilia number / MGI
  • abnormal inner hair cell stereociliary bundle morphology / MGI
  • fused inner hair cell stereocilia / MGI
  • decreased inner hair cell stereocilia number / MGI
  • abnormal cochlear hair cell inter-stereocilial links morphology / MGI
  • absent cochlear hair bundle ankle links / MGI
  • abnormal cochlear basement membrane morphology / MGI
  • abnormal cochlear OHC efferent innervation pattern / MGI
  • absent distortion product otoacoustic emissions / MGI
  • increased susceptibility to age-related hearing loss / MGI
  • increased cochlear nerve compound action potential / MGI
  • absent linear vestibular evoked potential / MGI
  • abnormal behavior / MGI
  • head tilt / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • head tossing / MGI
  • hearing/vestibular/ear phenotype / MGI
  • jerky movement / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • absent startle reflex / MGI
  • abnormal auditory summating potential / MGI
  • vestibular ganglion hypoplasia / MGI
  • retinal rod cell degeneration / MGI
  • slow postnatal weight gain / MGI
  • retropulsion / MGI
  • increased food intake / MGI
  • increased fluid intake / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Literature references

  • Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells.;Self T, Mahony M, Fleming J, Walsh J, Brown S D, Steel K P, ;1998;Development (Cambridge, England);125;557-66; 9435277
  • Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.;Hasson T, Walsh J, Cable J, Mooseker M S, Brown S D, Steel K P, ;1997;Cell motility and the cytoskeleton;37;127-38; 9186010

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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