STOCK Maf^Ofl/H

Status	Available to order
EMMA ID	EM:00423
International strain name	STOCK Maf^Ofl/H
Alternative name	OFL
Strain type	Induced Mutant Strains : Radiation-induced
Allele/Transgene symbol	Maf^Ofl
Gene/Transgene symbol	Maf

Information from provider

Provider	Mary Lyon
Provider affiliation	MRC Mammalian Genetics Unit
Phenotypic information	Mice heterozygous for this mutation have opaque flecks in the lens of their eyes. Mice homozygous for this mutation have very small eyes, and most die at birth through a failure to feed. However, the survivors are small, trembly and develop nephritis.
References	A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding.;Lyon Mary F, Jamieson Robyn V, Perveen Rahat, Glenister Peter H, Griffiths Robert, Boyd Yvonne, Glimcher Laurie H, Favor Jack, Munier Francis L, Black Graeme C M, ;2003;Human molecular genetics;12;585-94; 12620964

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	heterozygous 102/H-Maf^Ofl/+, heterozygous (C3H/HeH x 101/H)F1
Stage of embryos	8-cell

Disease and phenotype information

MGI allele-associated human disease models

cataract 21 multiple types / DOID:0110256

Orphanet associated rare diseases, based on orthologous gene matching

Cataract-microcornea syndrome / Orphanet_1377
Cerulean cataract / Orphanet_98989
Pulverulent cataract / Orphanet_98984
Aymé-Gripp syndrome / Orphanet_1272

IMPC phenotypes (gene matching)

microphthalmia / IMPC
abnormal spleen morphology / IMPC
abnormal liver morphology / IMPC
enlarged spleen / IMPC
lymphoid hyperplasia / IMPC
increased grip strength / IMPC
preweaning lethality, complete penetrance / IMPC
abnormal blood vessel morphology / IMPC
abnormal placenta morphology / IMPC
enlarged kidney / IMPC
decreased prepulse inhibition / IMPC
enlarged ovary / IMPC
abnormal kidney morphology / IMPC
hyperplasia / IMPC
edema / IMPC
abnormal liver size / IMPC
abnormal ovary morphology / IMPC
urinary bladder obstruction / IMPC
increased freezing behavior / IMPC
abnormal placenta vasculature / IMPC
cataract / IMPC
enlarged heart / IMPC
small kidney / IMPC
abnormal heart morphology / IMPC
abnormal vitreous body morphology / IMPC
embryonic growth retardation / IMPC
increased circulating bilirubin level / IMPC
small spleen / IMPC
small liver / IMPC

MGI phenotypes (allele matching)

cataract / MGI
abnormal pupillary reflex / MGI
tremors / MGI
decreased body size / MGI
abnormal lens induction / MGI
microphthalmia / MGI
small pupils / MGI
increased urine glucose level / MGI
abnormal kidney morphology / MGI
tubular nephritis / MGI
dilated renal tubules / MGI
postnatal lethality, complete penetrance / MGI
neonatal lethality, incomplete penetrance / MGI

MGI phenotypes (gene matching)

shortened head / MGI
tremors / MGI
weakness / MGI
decreased body size / MGI
abnormal lens induction / MGI
abnormal lens vesicle development / MGI
microphthalmia / MGI
abnormal lens morphology / MGI
cataract / MGI
small lens / MGI
small pupils / MGI
abnormal eating behavior / MGI
increased urine glucose level / MGI
abnormal kidney morphology / MGI
abnormal pupillary reflex / MGI
tubular nephritis / MGI
dilated renal tubules / MGI
abnormal lens fiber morphology / MGI
abnormal corneal endothelium morphology / MGI
vision/eye phenotype / MGI
abnormal lens development / MGI
decreased interleukin-4 secretion / MGI
nuclear cataracts / MGI
postnatal lethality, complete penetrance / MGI
postnatal lethality, incomplete penetrance / MGI
neonatal lethality, complete penetrance / MGI
neonatal lethality, incomplete penetrance / MGI
perinatal lethality, incomplete penetrance / MGI
embryonic lethality during organogenesis, incomplete penetrance / MGI
lethality throughout fetal growth and development, incomplete penetrance / MGI
increased cornea thickness / MGI

Literature references

A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding.;Lyon Mary F, Jamieson Robyn V, Perveen Rahat, Glenister Peter H, Griffiths Robert, Boyd Yvonne, Glimcher Laurie H, Favor Jack, Munier Francis L, Black Graeme C M, ;2003;Human molecular genetics;12;585-94; 12620964

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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STOCK MafOfl/H