B6Dnk;B6N-Hdac1tm1a(EUCOMM)Wtsi/Ieg

Status

Available to order

EMMA IDEM:04097
Citation informationRRID:IMSR_EM:04097 

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International strain nameB6Dnk;B6N-Hdac1tm1a(EUCOMM)Wtsi/Ieg
Alternative nameEPD0028_5_G01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolHdac1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolHdac1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0028_5_G01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6Dnk males

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating cholesterol level / IMPC
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • decreased heart rate variability / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased circulating cholesterol level / IMPC
  • decreased exploration in new environment / IMPC
  • cardiovascular system phenotype / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal allantois morphology / MGI
  • embryonic growth arrest / MGI
  • no phenotypic analysis / MGI
  • abnormal cell cycle / MGI
  • embryonic growth retardation / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal head development / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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