B6Dnk;B6N-NfyaGt(EUCJ0004f10)Hmgu/Ieg

Status

Available to order

EMMA IDEM:04087
International strain nameB6Dnk;B6N-NfyaGt(EUCJ0004f10)Hmgu/Ieg
Alternative nameEUCJ0004f10
Strain typeGene-trap
Allele/Transgene symbolNfyaGt(EUCJ0004f10)Hmgu
Gene/Transgene symbolNfya
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone EUCJ0004f10. For further details on the construction of this clone see the page at HTGT. Removal of the targeting cassette using Flp recombinase is required to convert the targeted into a conditional allele. Click here for more information on EUCOMM final vectors.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6Dnk, wild-type C57BL/6Dnk
Stage of embryos2-cell

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased bone mineral density / IMPC
  • increased leukocyte cell number / IMPC
  • abnormal head morphology / IMPC
  • decreased body length / IMPC
  • decreased body weight / IMPC
  • abnormal startle reflex / IMPC
  • abnormal eye morphology / IMPC
  • abnormal retina pigmentation / IMPC
  • decreased circulating serum albumin level / IMPC
  • increased IgG1 level / IMPC
  • decreased grip strength / IMPC
  • increased circulating fructosamine level / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating serum albumin level / IMPC
  • decreased body weight / IMPC
  • abnormal head morphology / IMPC
  • abnormal eye morphology / IMPC
  • increased circulating calcium level / IMPC
  • abnormal retina pigmentation / IMPC
  • increased circulating creatinine level / IMPC
  • increased leukocyte cell number / IMPC
  • increased bone mineral density / IMPC
  • decreased body length / IMPC
  • decreased grip strength / IMPC
  • abnormal startle reflex / IMPC
  • increased circulating fructosamine level / IMPC
  • thrombocytosis / IMPC
  • increased IgG1 level / IMPC
MGI phenotypes (allele matching)
  • no phenotypic analysis / MGI
MGI phenotypes (gene matching)
  • no phenotypic analysis / MGI
  • embryonic lethality, complete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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