FVB;129P2-Nf2tm2Gth/Cnrm

Status

Available to order

EMMA IDEM:00408
Citation informationRRID:IMSR_EM:00408 

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International strain nameFVB;129P2-Nf2tm2Gth/Cnrm
Alternative nameNf2F
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolNf2tm2Gth
Gene/Transgene symbolNf2

Information from provider

ProviderAnton Berns
Provider affiliationResearch - Animal Facility, The Netherlands Cancer Institute
Genetic informationInsertion of loxP sequences into intron 2 and 3.
Phenotypic informationConditional Nf2 knock-out, no phenotype.
References
  • Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.;Giovannini M, Robanus-Maandag E, van der Valk M, Niwa-Kawakita M, Abramowski V, Goutebroze L, Woodruff J M, Berns A, Thomas G, ;2000;Genes & development;14;1617-30; 10887156

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
Animals used for archivingheterozygous FVB/N males, wild-type FVB/N females
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal tooth development / MGI
  • impaired coordination / MGI
  • absent mesoderm / MGI
  • failure to gastrulate / MGI
  • abnormal dorsal-ventral axis patterning / MGI
  • abnormal placenta morphology / MGI
  • increased thermal nociceptive threshold / MGI
  • neoplasm / MGI
  • increased malignant tumor incidence / MGI
  • increased lung adenocarcinoma incidence / MGI
  • increased neurofibrosarcoma incidence / MGI
  • increased sarcoma incidence / MGI
  • increased carcinoma incidence / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • disorganized extraembryonic tissue / MGI
  • absent extraembryonic ectoderm / MGI
  • small ectoplacental cone / MGI
  • abnormal renal tubule morphology / MGI
  • nervous system phenotype / MGI
  • increased osteosarcoma incidence / MGI
  • abnormal osteoblast morphology / MGI
  • abnormal action potential / MGI
  • abnormal axon morphology / MGI
  • increased mesothelioma incidence / MGI
  • increased osteoma incidence / MGI
  • increased neurofibroma incidence / MGI
  • osseous metaplasia / MGI
  • increased fibrosarcoma incidence / MGI
  • increased fibroadenoma incidence / MGI
  • increased renal carcinoma incidence / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
  • abnormal visceral endoderm morphology / MGI
  • increased lymphoma incidence / MGI

Literature references

  • Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.;Giovannini M, Robanus-Maandag E, van der Valk M, Niwa-Kawakita M, Abramowski V, Goutebroze L, Woodruff J M, Berns A, Thomas G, ;2000;Genes & development;14;1617-30; 10887156

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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