IMPC phenotypes (gene matching)
FVB;129P2-Cdkn2atm2Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:00407 |
| Citation information | RRID:IMSR_EM:00407 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB;129P2-Cdkn2atm2Brn/Cnrm |
| Alternative name | I4aF |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Cdkn2atm2Brn |
| Gene/Transgene symbol | Cdkn2a |
Information from provider
| Provider | Anton Berns |
| Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
| Genetic information | Exons 2 and 3 are flanked by loxP sites. |
| Phenotypic information | Conditional p16ink4a and p19Arf knock-out, no phenotype |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- extramedullary hematopoiesis / MGI
- abnormal spleen morphology / MGI
- thymus hyperplasia / MGI
- hindlimb paralysis / MGI
- abnormal retinal photoreceptor morphology / MGI
- increased metastatic potential / MGI
- microphthalmia / MGI
- abnormal lens morphology / MGI
- cataract / MGI
- abnormal retina morphology / MGI
- male infertility / MGI
- blindness / MGI
- neoplasm / MGI
- increased papilloma incidence / MGI
- abnormal tumor incidence / MGI
- increased tumor incidence / MGI
- increased B cell derived lymphoma incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased sarcoma incidence / MGI
- increased fibrohistocytoma incidence / MGI
- increased carcinoma incidence / MGI
- seizures / MGI
- premature death / MGI
- abnormal eye morphology / MGI
- abnormal spleen red pulp morphology / MGI
- abnormal sperm number / MGI
- oligozoospermia / MGI
- no phenotypic analysis / MGI
- abnormal cell cycle / MGI
- retinal detachment / MGI
- testicular atrophy / MGI
- abnormal lens capsule morphology / MGI
- abnormal keratinocyte physiology / MGI
- increased hemangiosarcoma incidence / MGI
- increased tumor growth/size / MGI
- abnormal retinal inner nuclear layer morphology / MGI
- increased osteosarcoma incidence / MGI
- increased squamous cell carcinoma incidence / MGI
- increased incidence of tumors by chemical induction / MGI
- increased incidence of tumors by ionizing radiation induction / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased testis weight / MGI
- decreased testis weight / MGI
- increased thymus weight / MGI
- increased double-positive T cell number / MGI
- abnormal posterior eye segment morphology / MGI
- abnormal retinal ganglion layer morphology / MGI
- reproductive system phenotype / MGI
- vision/eye phenotype / MGI
- abnormal skin physiology / MGI
- abnormal lens development / MGI
- abnormal cell physiology / MGI
- abnormal retinal neuronal layer morphology / MGI
- binocular blindness / MGI
- abnormal spermatocyte morphology / MGI
- delayed cellular replicative senescence / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased spleen white pulp amount / MGI
- increased lung carcinoma incidence / MGI
- increased brain tumor incidence / MGI
- increased small lymphocytic lymphoma incidence / MGI
- increased histiocytic sarcoma incidence / MGI
- increased splenocyte proliferation / MGI
- increased gastrointestinal stromal tumor incidence / MGI
- primary vitreous hyperplasia / MGI
- increased melanoma incidence / MGI
- increased cutaneous melanoma incidence / MGI
- increased acute lymphoblastic leukemia incidence / MGI
- increased fibrosarcoma incidence / MGI
- persistent hyperplastic primary vitreous / MGI
- increased fibroblast proliferation / MGI
- increased lymphoma incidence / MGI
Literature references
- Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.;Krimpenfort P, Quon K C, Mooi W J, Loonstra A, Berns A, ;2001;Nature;413;83-6; 11544530
- A Versatile ES Cell-Based Melanoma Mouse Modeling Platform.;Bok Ilah, Vera Olga, Xu Xiaonan, Jasani Neel, Nakamura Koji, Reff Jordan, Nenci Arianna, Gonzalez Jose G, Karreth Florian A, ;2020;Cancer research;80;912-921; 31744817