FVB;129P2-Ptentm1Mro/Cnrm

Status

Available to order

EMMA IDEM:00406
Citation informationRRID:IMSR_EM:00406 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameFVB;129P2-Ptentm1Mro/Cnrm
Alternative namePtnF
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolPtentm1Mro
Gene/Transgene symbolPten

Information from provider

ProviderAnton Berns
Provider affiliationResearch - Animal Facility, The Netherlands Cancer Institute
Genetic informationA 9 kb fragment containing a neomycin selection cassette flanked by loxP sites and a loxP sequence placed 1.3 kb downstream of exon 5 of the Pten gene, was electroporated into ES cells (129 origin), resulting in the insertion of loxP sites into the fourth and the fifth intron, flanking exon 5.
Phenotypic informationConditional Pten knock-out, no phenotype.
References
  • PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.;Marino Silvia, Krimpenfort Paul, Leung Carly, van der Korput Hetty A G M, Trapman Jan, Camenisch Isabelle, Berns Anton, Brandner Sebastian, ;2002;Development (Cambridge, England);129;3513-22; 12091320

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal pericardium morphology / MGI
  • increased cell proliferation / MGI
  • megacephaly / MGI
  • prostate gland hyperplasia / MGI
  • abnormal thyroid gland morphology / MGI
  • lymphoid hyperplasia / MGI
  • enlarged spleen / MGI
  • enlarged thymus / MGI
  • abnormal olfactory bulb morphology / MGI
  • altered metastatic potential / MGI
  • abnormal brain development / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal uterus morphology / MGI
  • abnormal prostate gland morphology / MGI
  • prostate gland epithelial hyperplasia / MGI
  • abnormal prostate gland epithelium morphology / MGI
  • decreased body size / MGI
  • increased metastatic potential / MGI
  • abnormal social investigation / MGI
  • increased stereotypic behavior / MGI
  • impaired balance / MGI
  • abnormal embryo development / MGI
  • abnormal somite development / MGI
  • abnormal gastrulation / MGI
  • decreased embryo size / MGI
  • incomplete embryo turning / MGI
  • abnormal placenta morphology / MGI
  • abnormal allantois morphology / MGI
  • embryonic growth arrest / MGI
  • increased mammary adenocarcinoma incidence / MGI
  • increased malignant tumor incidence / MGI
  • abnormal tumor incidence / MGI
  • increased tumor incidence / MGI
  • increased T cell derived lymphoma incidence / MGI
  • increased leukemia incidence / MGI
  • increased adrenal gland tumor incidence / MGI
  • increased carcinoma incidence / MGI
  • increased pheochromocytoma incidence / MGI
  • premature death / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • increased brain weight / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal seminiferous tubule morphology / MGI
  • abnormal lymph node B cell domain morphology / MGI
  • increased teratoma incidence / MGI
  • abnormal synaptic depression / MGI
  • increased hemangioma incidence / MGI
  • colon polyps / MGI
  • increased liver adenoma incidence / MGI
  • astrocytosis / MGI
  • kinked neural tube / MGI
  • increased thyroid adenoma incidence / MGI
  • abnormal microglial cell physiology / MGI
  • decreased aggression towards males / MGI
  • embryonic growth retardation / MGI
  • disorganized embryonic tissue / MGI
  • failure of initiation of embryo turning / MGI
  • cardia bifida / MGI
  • increased incidence of tumors by ionizing radiation induction / MGI
  • enlarged allantois / MGI
  • abnormal thyroid follicular cell morphology / MGI
  • increased endometrial carcinoma incidence / MGI
  • abnormal behavior / MGI
  • abnormal brain vasculature morphology / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • increased brain size / MGI
  • abnormal cell physiology / MGI
  • increased mammary adenoacanthoma incidence / MGI
  • intestine polyps / MGI
  • lymph node hyperplasia / MGI
  • enlarged Peyer's patches / MGI
  • abnormal cerebral hemisphere morphology / MGI
  • embryonic lethality / MGI
  • enlarged cerebellum / MGI
  • endometrium hyperplasia / MGI
  • decreased prepulse inhibition / MGI
  • increased prostate intraepithelial neoplasia incidence / MGI
  • increased uterus carcinoma incidence / MGI
  • failure of chorioallantoic fusion / MGI
  • abnormal hippocampus granule cell morphology / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • abnormal cerebral cortex pyramidal cell morphology / MGI
  • increased oligodendrocyte number / MGI
  • increased gastrointestinal tumor incidence / MGI
  • increased mammary gland tumor incidence / MGI
  • increased stomach tumor incidence / MGI
  • increased hamartoma incidence / MGI
  • increased thyroid tumor incidence / MGI
  • increased thyroid carcinoma incidence / MGI
  • increased prostate gland tumor incidence / MGI
  • increased fibroadenoma incidence / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • increased astrocyte number / MGI
  • increased lymphoma incidence / MGI

Literature references

  • PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.;Marino Silvia, Krimpenfort Paul, Leung Carly, van der Korput Hetty A G M, Trapman Jan, Camenisch Isabelle, Berns Anton, Brandner Sebastian, ;2002;Development (Cambridge, England);129;3513-22; 12091320
  • MYC deficiency impairs the development of effector/memory T lymphocytes.;Nozais Mathis, Loosveld Marie, Pankaew Saran, Grosjean Clémence, Gentil Noémie, Quessada Julie, Nadel Bertrand, Mionnet Cyrille, Potier Delphine, Payet-Bornet Dominique, ;2021;iScience;24;102761; 34258568
  • Multiplexed single-cell RNA-sequencing of mouse thymic and splenic samples.;Pankaew Saran, Grosjean Clémence, Quessada Julie, Loosveld Marie, Potier Delphine, Payet-Bornet Dominique, Nozais Mathis, ;2021;STAR protocols;3;101041; 36475567

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).