C57BL/6NTac-Cidectm1a(EUCOMM)Wtsi/Cnrm

Status

Available to order

EMMA IDEM:04019
Citation informationRRID:IMSR_EM:04019 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Cidectm1a(EUCOMM)Wtsi/Cnrm
Alternative nameEPD0116_3_D06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCidectm1a(EUCOMM)Wtsi
Gene/Transgene symbolCidec
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0116_3_D06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased fasting circulating glucose level / IMPC
  • decreased total body fat amount / IMPC
  • increased lean body mass / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • persistence of hyaloid vascular system / IMPC
  • abnormal optic disk morphology / IMPC
  • abnormal auditory brainstem response / IMPC
  • increased circulating cholesterol level / IMPC
  • increased mean corpuscular volume / IMPC
MGI phenotypes (gene matching)
  • decreased white adipose tissue amount / MGI
  • no abnormal phenotype detected / MGI
  • decreased susceptibility to hepatic steatosis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • increased insulin sensitivity / MGI
  • abnormal white adipose tissue morphology / MGI
  • abnormal brown adipose tissue morphology / MGI
  • decreased susceptibility to age related obesity / MGI
  • decreased circulating ketone body level / MGI
  • increased energy expenditure / MGI
  • increased oxygen consumption / MGI
  • improved glucose tolerance / MGI
  • abnormal fat pad morphology / MGI
  • abnormal gonadal fat pad morphology / MGI
  • vision/eye phenotype / MGI
  • increased body temperature / MGI
  • decreased circulating glucose level / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • decreased circulating leptin level / MGI
  • enhanced lipolysis / MGI
  • decreased subcutaneous adipose tissue amount / MGI
  • abnormal fat cell morphology / MGI
  • decreased gonadal fat pad weight / MGI
  • decreased inguinal fat pad weight / MGI
  • decreased mesenteric fat pad weight / MGI
  • decreased retroperitoneal fat pad weight / MGI
  • abnormal blood homeostasis / MGI
  • decreased total body fat amount / MGI
  • increased respiratory quotient / MGI
  • integument phenotype / MGI
  • impaired adaptive thermogenesis / MGI
  • increased food intake / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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