B6D2-Tg(PySTdeltaMT)82Poz/Cnrm

Status	Available to order
EMMA ID	EM:00401
Citation information	RRID:IMSR_EM:00401 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6D2-Tg(PySTdeltaMT)82Poz/Cnrm
Alternative name	TG Py AS Fo82
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(PySTdeltaMT)82Poz
Gene/Transgene symbol	Tg(PySTdeltaMT)82Poz

Information from provider

Provider	Laura POZZI
Provider affiliation	Centro Ricerca Sperimentale - Istituto Regina Elena
Genetic information	See publication: Felici A et al. Medullary thyroid carcinoma in transgenic mice expressing a Polyoma carboxyl-terminal truncated middle-T and wild-type small-T antigens. Oncogene 18, 2387-2395, 1999.
Phenotypic information	medullary thyroid carcinoma (tumor onset: 3-4 months), lethal by month 5-7 (full penetrance); - wavy hair and whiskers (full penetrance); - mild eye cataract, onset by week 4-5 (about 80% penetrance).
Breeding history	Heterozygous males (genotyped by coat phenotype or the presence of cataract) are mated with wild-type B6DF1 females. Females are usually discarded from litters early after birth, since they are not used for transgene transmission. It is preferable to maintain the transgene in heterozygotes since homozygotes develop the tumor faster and die earlier. Life span of heterozygotes is usually 6-8 months.
References	Medullary thyroid carcinomas in transgenic mice expressing a Polyoma carboxyl-terminal truncated middle-T and wild type small-T antigens.;Felici A, Giorgio M, Krauzewicz N, Della Rocca C, Santoro M, Rovere P, Manni I, Amati P, Pozzi L, ;1999;Oncogene;18;2387-95; 10327060

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

Medullary thyroid carcinomas in transgenic mice expressing a Polyoma carboxyl-terminal truncated middle-T and wild type small-T antigens.;Felici A, Giorgio M, Krauzewicz N, Della Rocca C, Santoro M, Rovere P, Manni I, Amati P, Pozzi L, ;1999;Oncogene;18;2387-95; 10327060

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Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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