B6.129S2-H2-Ab1tm1Doi/DoiOrl
Status | Available to order |
EMMA ID | EM:00004 |
International strain name | B6.129S2-H2-Ab1tm1Doi/DoiOrl |
Alternative name | Abeta° |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | H2-Ab1b-tm1Doi, |
Gene/Transgene symbol | H2-Ab1 |
Information from provider
Provider | Diane MATHIS |
Provider affiliation | LGME Universite |
Phenotypic information | Mutant mice deficient in histocompatibility 2, class II antigen A, beta 1 (MHC class II A beta, H2-Ab1) gene. H2-Ab1 gene mutation obtained by homologous recombination (insertion of neomycin-resistance gene cassette into the second exon) in ES cells from 129S2/SvPas, yet deficient in the MHC complex. The animals show a complete lack of class II molecules and an almost total absence of CD4+ lymphocytes. Immune responses are much altered or lacking. |
Breeding history | 129S2/SvPas ES cells; 9 generations of backcross with C57BL/6, then intercross. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
Stage of embryos | 2-cell |
Literature references
- Mice lacking MHC class II molecules.;Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D, ;1991;Cell;66;1051-66; 1909605
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