STOCK Utrn^tm1Ked Dmd^mdx Tg(Ckm-Dmd*)11956Chmb/H

Status	Available to order
EMMA ID	EM:00392
International strain name	STOCK Utrn^tm1Ked Dmd^mdx Tg(Ckm-Dmd*)11956Chmb/H
Alternative name	CVBA
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Ckm-Dmd*)11956Chmb, Dmd^mdx, Utrn^tm1Ked
Gene/Transgene symbol	Tg(Ckm-Dmd*)11956Chmb, Dmd, Utrn

Information from provider

Provider	Kay Davies
Provider affiliation	University of Oxford
Genetic information	Tg(CVBA3)Ked/mdx mice are transgenic for a dystrophin cDNA transgene, with a deletion of exons 17-48 and under the control of the Ckm (or MCK) promoter, i.e. inducible by the withdrawal or administration of tetracycline in the drinking water.
Phenotypic information	Tg(CVBA3)Ked/mdx mice are transgenic for a dystrophin cDNA transgene, with a deletion of exons 17-48 and under the control of the MCK promoter, i.e. inducible by the withdrawal or administration of tetracycline in the drinking water.
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Familial isolated dilated cardiomyopathy / Orphanet_154
Duchenne muscular dystrophy / Orphanet_98896
Becker muscular dystrophy / Orphanet_98895
X-linked non-syndromic intellectual disability / Orphanet_777
Symptomatic form of muscular dystrophy of Duchenne and Becker in female carriers / Orphanet_206546

IMPC phenotypes (gene matching)

increased circulating alanine transaminase level / IMPC
increased lean body mass / IMPC
increased circulating serum albumin level / IMPC
decreased total body fat amount / IMPC
decreased mean corpuscular volume / IMPC
decreased mean corpuscular hemoglobin / IMPC
thrombocytosis / IMPC
decreased bone mineral content / IMPC
increased red blood cell distribution width / IMPC
increased circulating aspartate transaminase level / IMPC
increased circulating total protein level / IMPC
abnormal bone structure / IMPC
decreased grip strength / IMPC
increased circulating alkaline phosphatase level / IMPC

MGI phenotypes (allele matching)

abnormal skeletal muscle fiber morphology / MGI
dystrophic muscle / MGI
abnormal circulating pyruvate kinase level / MGI
muscle degeneration / MGI
myopathy / MGI
reduced female fertility / MGI
abnormal muscle physiology / MGI
abnormal muscle morphology / MGI
muscular atrophy / MGI
skeletal muscle necrosis / MGI
dilated sarcoplasmic reticulum / MGI
increased variability of skeletal muscle fiber size / MGI
skeletal muscle fibrosis / MGI
increased circulating creatine kinase level / MGI
decreased aerobic running capacity / MGI
increased skeletal muscle mass / MGI
increased growth hormone level / MGI
muscle phenotype / MGI
adipose tissue phenotype / MGI
homeostasis/metabolism phenotype / MGI
myocardial necrosis / MGI
abnormal corticotroph morphology / MGI
increased somatotroph cell size / MGI
centrally nucleated skeletal muscle fibers / MGI
increased skeletal muscle fiber number / MGI
skeletal muscle fiber necrosis / MGI
increased quadriceps weight / MGI
increased skeletal muscle weight / MGI
enlarged heart / MGI
increased body size / MGI
impaired coordination / MGI
abnormal grip strength / MGI
impaired skeletal muscle contractility / MGI
calcified muscle / MGI
decreased cardiac output / MGI
myositis / MGI
increased susceptibility to noise-induced hearing loss / MGI
decreased cardiac muscle contractility / MGI
cardiomyopathy / MGI
cardiovascular system phenotype / MGI
increased tumor necrosis factor secretion / MGI
increased interferon-gamma secretion / MGI
increased interleukin-12 secretion / MGI
increased interleukin-2 secretion / MGI
increased interleukin-4 secretion / MGI
increased interleukin-6 secretion / MGI
increased skeletal muscle fiber diameter / MGI
skeletal muscle degeneration / MGI
skeletal muscle hypertrophy / MGI
decreased grip strength / MGI
decreased cardiac stroke volume / MGI
abnormal auditory brainstem response waveform shape / MGI
increased or absent threshold for auditory brainstem response / MGI
abnormal skeletal muscle regeneration / MGI
increased creatine kinase activity / MGI
decreased body size / MGI
heart inflammation / MGI
dystrophic cardiac calcinosis / MGI
decreased skeletal muscle mass / MGI
decreased skeletal muscle fiber size / MGI
decreased skeletal muscle fiber diameter / MGI
skeletal muscle fiber atrophy / MGI
cardiac muscle degeneration / MGI
skeletal muscle atrophy / MGI
abnormal skeletal muscle morphology / MGI
abnormal neuromuscular synapse morphology / MGI
abnormal diaphragm morphology / MGI
abnormal intercostal muscle morphology / MGI
nervous system phenotype / MGI
abnormal muscle tone / MGI
abnormal muscle electrophysiology / MGI
abnormal muscle contractility / MGI
decreased physiological sensitivity to xenobiotic / MGI
abnormal skeletal muscle satellite cell proliferation / MGI
skeletal muscle endomysial fibrosis / MGI
anterior subcapsular cataracts / MGI
nuclear cataracts / MGI
abnormal scalene muscle morphology / MGI
abnormal vertebral column morphology / MGI
increased transforming growth factor level / MGI
skeletal muscle fiber degeneration / MGI
impaired exercise endurance / MGI
muscle weakness / MGI
decreased body weight / MGI
decreased skeletal muscle fiber number / MGI
increased total body fat amount / MGI
decreased quadriceps weight / MGI
decreased skeletal muscle weight / MGI
abnormal miniature endplate potential / MGI
renal/urinary system phenotype / MGI
respiratory system phenotype / MGI

MGI phenotypes (gene matching)

enlarged heart / MGI
abnormal myocardial fiber morphology / MGI
abnormal myogenesis / MGI
increased satellite cell number / MGI
abnormal muscle development / MGI
muscle weakness / MGI
muscle degeneration / MGI
myopathy / MGI
dystrophic muscle / MGI
abnormal skeletal muscle morphology / MGI
abnormal neuromuscular synapse morphology / MGI
decreased body weight / MGI
increased body size / MGI
decreased body size / MGI
impaired coordination / MGI
abnormal grip strength / MGI
heart inflammation / MGI
myocarditis / MGI
reduced fertility / MGI
reduced female fertility / MGI
decreased litter size / MGI
abnormal muscle physiology / MGI
abnormal muscle morphology / MGI
abnormal cardiovascular system morphology / MGI
no abnormal phenotype detected / MGI
muscular atrophy / MGI
abnormal diaphragm morphology / MGI
abnormal intercostal muscle morphology / MGI
decreased susceptibility to viral infection / MGI
dystrophic cardiac calcinosis / MGI
impaired skeletal muscle contractility / MGI
thick ventricular wall / MGI
no phenotypic analysis / MGI
decreased aerobic running capacity / MGI
abnormal skeletal muscle fiber morphology / MGI
abnormal heart atrium morphology / MGI
calcified muscle / MGI
decreased cardiac output / MGI
nervous system phenotype / MGI
skeletal muscle necrosis / MGI
abnormal plasma membrane morphology / MGI
prolonged P wave / MGI
abnormal muscle fiber morphology / MGI
dilated sarcoplasmic reticulum / MGI
abnormal sarcolemma morphology / MGI
abnormal muscle tone / MGI
abnormal muscle electrophysiology / MGI
abnormal myocardial fiber physiology / MGI
myositis / MGI
increased susceptibility to noise-induced hearing loss / MGI
abnormal vertebral column morphology / MGI
increased skeletal muscle mass / MGI
decreased skeletal muscle mass / MGI
increased growth hormone level / MGI
decreased cardiac muscle contractility / MGI
cardiomyopathy / MGI
muscle phenotype / MGI
adipose tissue phenotype / MGI
homeostasis/metabolism phenotype / MGI
cardiovascular system phenotype / MGI
abnormal Muller cell morphology / MGI
abnormal muscle contractility / MGI
myocardial necrosis / MGI
retinal ischemia / MGI
abnormal corticotroph morphology / MGI
increased somatotroph cell size / MGI
increased tumor necrosis factor secretion / MGI
increased interferon-gamma secretion / MGI
increased interleukin-12 secretion / MGI
increased interleukin-2 secretion / MGI
increased interleukin-4 secretion / MGI
increased interleukin-6 secretion / MGI
increased transforming growth factor level / MGI
decreased physiological sensitivity to xenobiotic / MGI
decreased skeletal muscle fiber size / MGI
increased skeletal muscle fiber diameter / MGI
decreased skeletal muscle fiber diameter / MGI
increased variability of skeletal muscle fiber size / MGI
centrally nucleated skeletal muscle fibers / MGI
increased skeletal muscle fiber number / MGI
decreased skeletal muscle fiber number / MGI
abnormal skeletal muscle satellite cell proliferation / MGI
skeletal muscle fiber degeneration / MGI
skeletal muscle fiber atrophy / MGI
skeletal muscle fiber necrosis / MGI
skeletal muscle degeneration / MGI
cardiac muscle degeneration / MGI
skeletal muscle atrophy / MGI
skeletal muscle fibrosis / MGI
skeletal muscle endomysial fibrosis / MGI
skeletal muscle hypertrophy / MGI
increased total body fat amount / MGI
decreased grip strength / MGI
increased circulating creatine kinase level / MGI
abnormal circulating pyruvate kinase level / MGI
increased quadriceps weight / MGI
decreased quadriceps weight / MGI
increased skeletal muscle weight / MGI
decreased skeletal muscle weight / MGI
anterior subcapsular cataracts / MGI
nuclear cataracts / MGI
prolonged QRS complex duration / MGI
decreased P wave amplitude / MGI
abnormal atrium myocardial trabeculae morphology / MGI
preweaning lethality, incomplete penetrance / MGI
decreased cardiac stroke volume / MGI
abnormal auditory brainstem response waveform shape / MGI
increased or absent threshold for auditory brainstem response / MGI
impaired exercise endurance / MGI
abnormal skeletal muscle regeneration / MGI
increased creatine kinase activity / MGI
abnormal scalene muscle morphology / MGI
abnormal neuromuscular synapse morphology / MGI
abnormal nervous system physiology / MGI
abnormal miniature endplate potential / MGI
renal/urinary system phenotype / MGI
muscle phenotype / MGI
respiratory system phenotype / MGI
increased sensitivity to xenobiotic induced morbidity/mortality / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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STOCK Utrntm1Ked Dmdmdx Tg(Ckm-Dmd*)11956Chmb/H