B;CBACa-Dmdmdx Tg(CKMM-tTA)A3Rhvh Tg(tetO-Utrn)1Ked/H

Status

Available to order

EMMA IDEM:00389
International strain nameB;CBACa-Dmdmdx Tg(CKMM-tTA)A3Rhvh Tg(tetO-Utrn)1Ked/H
Alternative nameMCK
Strain typeTransgenic Strains
Allele/Transgene symbolTg(CKMM-tTA)A3Rhvh, Dmdmdx, Tg(tetO-Utrn)1Ked
Gene/Transgene symbolTg(CKMM-tTA)A3Rhvh, Dmd, Tg(tetO-Utrn)1Ked

Information from provider

ProviderKay Davies
Provider affiliationUniversity of Oxford
Genetic informationMCK-tTA/mdx mice contain the muscle specific creatine kinase (MCK or CKMM) promoter driving the tetracycline transactivator (tTA).
Phenotypic informationMCK-tTA mice contain the muscle specific creatine kinase (MCK or CKMM) promoter driving the tetracycline transactivator (tTA). These mice were bred onto Dmdmdx mice and then mated with mice containing a utrophin transgene which is inducible by the withdrawal or administration of tetracycline in drinking water. Under these conditions the MCK promoter gives a mosaic expression of utrophin at levels which significantly improve the pathology of the Dmdmdx mice but do not entirely prevent the dystrophic symptoms.
References
  • Prevention of pathology in mdx mice by expression of utrophin: analysis using an inducible transgenic expression system.;Squire S, Raymackers J M, Vandebrouck C, Potter A, Tinsley J, Fisher R, Gillis J M, Davies K E, ;2002;Human molecular genetics;11;3333-44; 12471059

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating alanine transaminase level / IMPC
  • increased lean body mass / IMPC
  • increased circulating serum albumin level / IMPC
  • decreased total body fat amount / IMPC
  • decreased mean corpuscular volume / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • thrombocytosis / IMPC
  • decreased bone mineral content / IMPC
  • increased red blood cell distribution width / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased circulating total protein level / IMPC
  • abnormal bone structure / IMPC
  • decreased grip strength / IMPC
  • increased circulating alkaline phosphatase level / IMPC
MGI phenotypes (allele matching)
  • abnormal skeletal muscle fiber morphology / MGI
  • dystrophic muscle / MGI
  • abnormal circulating pyruvate kinase level / MGI
  • muscle degeneration / MGI
  • myopathy / MGI
  • reduced female fertility / MGI
  • abnormal muscle physiology / MGI
  • abnormal muscle morphology / MGI
  • muscular atrophy / MGI
  • skeletal muscle necrosis / MGI
  • dilated sarcoplasmic reticulum / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • skeletal muscle fibrosis / MGI
  • increased circulating creatine kinase level / MGI
  • decreased aerobic running capacity / MGI
  • increased skeletal muscle mass / MGI
  • increased growth hormone level / MGI
  • muscle phenotype / MGI
  • adipose tissue phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • myocardial necrosis / MGI
  • abnormal corticotroph morphology / MGI
  • increased somatotroph cell size / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • increased skeletal muscle fiber number / MGI
  • skeletal muscle fiber necrosis / MGI
  • increased quadriceps weight / MGI
  • increased skeletal muscle weight / MGI
  • enlarged heart / MGI
  • increased body size / MGI
  • impaired coordination / MGI
  • abnormal grip strength / MGI
  • impaired skeletal muscle contractility / MGI
  • calcified muscle / MGI
  • decreased cardiac output / MGI
  • myositis / MGI
  • increased susceptibility to noise-induced hearing loss / MGI
  • decreased cardiac muscle contractility / MGI
  • cardiomyopathy / MGI
  • cardiovascular system phenotype / MGI
  • increased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • increased interleukin-12 secretion / MGI
  • increased interleukin-2 secretion / MGI
  • increased interleukin-4 secretion / MGI
  • increased interleukin-6 secretion / MGI
  • increased skeletal muscle fiber diameter / MGI
  • skeletal muscle degeneration / MGI
  • skeletal muscle hypertrophy / MGI
  • decreased grip strength / MGI
  • decreased cardiac stroke volume / MGI
  • abnormal auditory brainstem response waveform shape / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • abnormal skeletal muscle regeneration / MGI
  • increased creatine kinase activity / MGI
  • decreased body size / MGI
  • heart inflammation / MGI
  • dystrophic cardiac calcinosis / MGI
  • decreased skeletal muscle mass / MGI
  • decreased skeletal muscle fiber size / MGI
  • decreased skeletal muscle fiber diameter / MGI
  • skeletal muscle fiber atrophy / MGI
  • cardiac muscle degeneration / MGI
  • skeletal muscle atrophy / MGI
  • abnormal skeletal muscle morphology / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • abnormal diaphragm morphology / MGI
  • abnormal intercostal muscle morphology / MGI
  • nervous system phenotype / MGI
  • abnormal muscle tone / MGI
  • abnormal muscle electrophysiology / MGI
  • abnormal muscle contractility / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • abnormal skeletal muscle satellite cell proliferation / MGI
  • skeletal muscle endomysial fibrosis / MGI
  • anterior subcapsular cataracts / MGI
  • nuclear cataracts / MGI
  • abnormal scalene muscle morphology / MGI
  • abnormal vertebral column morphology / MGI
  • increased transforming growth factor level / MGI
  • skeletal muscle fiber degeneration / MGI
  • impaired exercise endurance / MGI
  • muscle weakness / MGI
  • decreased body weight / MGI
  • decreased skeletal muscle fiber number / MGI
  • increased total body fat amount / MGI
  • decreased quadriceps weight / MGI
  • decreased skeletal muscle weight / MGI
MGI phenotypes (gene matching)
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • abnormal myogenesis / MGI
  • increased satellite cell number / MGI
  • abnormal muscle development / MGI
  • muscle weakness / MGI
  • muscle degeneration / MGI
  • myopathy / MGI
  • dystrophic muscle / MGI
  • abnormal skeletal muscle morphology / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • decreased body weight / MGI
  • increased body size / MGI
  • decreased body size / MGI
  • impaired coordination / MGI
  • abnormal grip strength / MGI
  • heart inflammation / MGI
  • myocarditis / MGI
  • reduced fertility / MGI
  • reduced female fertility / MGI
  • decreased litter size / MGI
  • abnormal muscle physiology / MGI
  • abnormal muscle morphology / MGI
  • abnormal cardiovascular system morphology / MGI
  • no abnormal phenotype detected / MGI
  • muscular atrophy / MGI
  • abnormal diaphragm morphology / MGI
  • abnormal intercostal muscle morphology / MGI
  • decreased susceptibility to viral infection / MGI
  • dystrophic cardiac calcinosis / MGI
  • impaired skeletal muscle contractility / MGI
  • thick ventricular wall / MGI
  • no phenotypic analysis / MGI
  • decreased aerobic running capacity / MGI
  • abnormal skeletal muscle fiber morphology / MGI
  • abnormal heart atrium morphology / MGI
  • calcified muscle / MGI
  • decreased cardiac output / MGI
  • nervous system phenotype / MGI
  • skeletal muscle necrosis / MGI
  • abnormal plasma membrane morphology / MGI
  • prolonged P wave / MGI
  • abnormal muscle fiber morphology / MGI
  • dilated sarcoplasmic reticulum / MGI
  • abnormal sarcolemma morphology / MGI
  • abnormal muscle tone / MGI
  • abnormal muscle electrophysiology / MGI
  • abnormal myocardial fiber physiology / MGI
  • myositis / MGI
  • increased susceptibility to noise-induced hearing loss / MGI
  • abnormal vertebral column morphology / MGI
  • increased skeletal muscle mass / MGI
  • decreased skeletal muscle mass / MGI
  • increased growth hormone level / MGI
  • decreased cardiac muscle contractility / MGI
  • cardiomyopathy / MGI
  • muscle phenotype / MGI
  • adipose tissue phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • cardiovascular system phenotype / MGI
  • abnormal Muller cell morphology / MGI
  • abnormal muscle contractility / MGI
  • myocardial necrosis / MGI
  • retinal ischemia / MGI
  • abnormal corticotroph morphology / MGI
  • increased somatotroph cell size / MGI
  • increased tumor necrosis factor secretion / MGI
  • increased interferon-gamma secretion / MGI
  • increased interleukin-12 secretion / MGI
  • increased interleukin-2 secretion / MGI
  • increased interleukin-4 secretion / MGI
  • increased interleukin-6 secretion / MGI
  • increased transforming growth factor level / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased skeletal muscle fiber size / MGI
  • increased skeletal muscle fiber diameter / MGI
  • decreased skeletal muscle fiber diameter / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • increased skeletal muscle fiber number / MGI
  • decreased skeletal muscle fiber number / MGI
  • abnormal skeletal muscle satellite cell proliferation / MGI
  • skeletal muscle fiber degeneration / MGI
  • skeletal muscle fiber atrophy / MGI
  • skeletal muscle fiber necrosis / MGI
  • skeletal muscle degeneration / MGI
  • cardiac muscle degeneration / MGI
  • skeletal muscle atrophy / MGI
  • skeletal muscle fibrosis / MGI
  • skeletal muscle endomysial fibrosis / MGI
  • skeletal muscle hypertrophy / MGI
  • increased total body fat amount / MGI
  • decreased grip strength / MGI
  • increased circulating creatine kinase level / MGI
  • abnormal circulating pyruvate kinase level / MGI
  • increased quadriceps weight / MGI
  • decreased quadriceps weight / MGI
  • increased skeletal muscle weight / MGI
  • decreased skeletal muscle weight / MGI
  • anterior subcapsular cataracts / MGI
  • nuclear cataracts / MGI
  • prolonged QRS complex duration / MGI
  • decreased P wave amplitude / MGI
  • abnormal atrium myocardial trabeculae morphology / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • decreased cardiac stroke volume / MGI
  • abnormal auditory brainstem response waveform shape / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • impaired exercise endurance / MGI
  • abnormal skeletal muscle regeneration / MGI
  • increased creatine kinase activity / MGI
  • abnormal scalene muscle morphology / MGI

Literature references

  • Prevention of pathology in mdx mice by expression of utrophin: analysis using an inducible transgenic expression system.;Squire S, Raymackers J M, Vandebrouck C, Potter A, Tinsley J, Fisher R, Gillis J M, Davies K E, ;2002;Human molecular genetics;11;3333-44; 12471059

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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