IMPC phenotypes (gene matching)
STOCK Foxn1nu/Orl
| Status | Available to order |
| EMMA ID | EM:00038 |
| International strain name | STOCK Foxn1nu/Orl |
| Alternative name | C57BL/6 - nu |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Foxn1nu |
| Gene/Transgene symbol | Foxn1 |
Information from provider
| Provider | CDTA unknown |
| Provider affiliation | CNRS-Orleans |
| Phenotypic information | Mutant strain with Foxn1 (forkhead box N1) nu allele (prev. nomenclature: nu, nude mutation). The nude mutation is a single, autosomal recessive mutation. The Foxn1nu locus is localized on chromosome 11. Congenic nude strains show the pleiotropic phenotype of hairlessness, athymia and T-cell deficiency. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous , heterozygous C57BL/6J |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to FOXN1 deficiency / Orphanet_169095
MGI phenotypes (allele matching)
- small thymus / MGI
- abnormal thymus morphology / MGI
- increased incidence of corneal inflammation / MGI
- increased susceptibility to viral infection / MGI
- blepharitis / MGI
- corneal vascularization / MGI
- abnormal nail morphology / MGI
- nail dystrophy / MGI
- abnormal nail plate morphology / MGI
- abnormal nail matrix morphology / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased leukocyte cell number / MGI
- abnormal liver morphology / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- athymia / MGI
- small ovary / MGI
- thin skin / MGI
- decreased body weight / MGI
- decreased body size / MGI
- wavy vibrissae / MGI
- short vibrissae / MGI
- absent vibrissae / MGI
- postnatal growth retardation / MGI
- reduced male fertility / MGI
- female infertility / MGI
- abnormal estrous cycle / MGI
- premature death / MGI
- abnormal lymph node T cell domain morphology / MGI
- abnormal Peyer's patch germinal center morphology / MGI
- asthenozoospermia / MGI
- hairless / MGI
- abnormal venule morphology / MGI
- abnormal splenic cell ratio / MGI
- coiled sperm flagellum / MGI
- postnatal lethality, incomplete penetrance / MGI
- impaired spatial learning / MGI
- increased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- abnormal compact bone morphology / MGI
- abnormal coat/ hair morphology / MGI
- abnormal hair follicle morphology / MGI
- deformed nails / MGI
- abnormal thymus development / MGI
- abnormal epidermal layer morphology / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cuticle / MGI
- abnormal hair cortex morphology / MGI
- endocrine/exocrine gland phenotype / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- reduced hair shaft melanin granule number / MGI
- abnormal hair cortex keratinization / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- short nails / MGI
- decreased susceptibility to bacterial infection / MGI
- decreased circulating alanine transaminase level / MGI
- ascites / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-2 level / MGI
- chromosomal instability / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal circulating cytokine level / MGI
- increased plasmacytoma incidence / MGI
- decreased circulating luteinizing hormone level / MGI
- decreased circulating follicle stimulating hormone level / MGI
- abnormal circulating gonadotropin level / MGI
- abnormal T cell activation / MGI
- abnormal lymph node morphology / MGI
- increased length of allograft survival / MGI
- decreased lymphocyte cell number / MGI
- decreased T cell number / MGI
- abnormal spleen physiology / MGI
- abnormal muscle morphology / MGI
- decreased skeletal muscle mass / MGI
- decreased skeletal muscle fiber size / MGI
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- abnormal leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- decreased leukocyte cell number / MGI
- increased granulocyte number / MGI
- abnormal coat/ hair morphology / MGI
- abnormal hair follicle morphology / MGI
- underdeveloped hair follicles / MGI
- abnormal nail morphology / MGI
- deformed nails / MGI
- abnormal liver morphology / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal thymus morphology / MGI
- abnormal thymus development / MGI
- athymia / MGI
- small thymus / MGI
- thymus hyperplasia / MGI
- decreased thymocyte number / MGI
- abnormal immune system cell morphology / MGI
- abnormal lymphocyte cell number / MGI
- small ovary / MGI
- thin skin / MGI
- wrinkled skin / MGI
- abnormal epidermal layer morphology / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- curly vibrissae / MGI
- wavy vibrissae / MGI
- short vibrissae / MGI
- sparse vibrissae / MGI
- absent vibrissae / MGI
- increased incidence of corneal inflammation / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- thymus hypoplasia / MGI
- abnormal T cell activation / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- female infertility / MGI
- abnormal estrous cycle / MGI
- decreased litter size / MGI
- increased sarcoma incidence / MGI
- abnormal hair growth / MGI
- premature death / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal skin pigmentation / MGI
- abnormal vibrissa morphology / MGI
- abnormal muscle morphology / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal lymph node morphology / MGI
- abnormal lymph node T cell domain morphology / MGI
- abnormal Peyer's patch germinal center morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- decreased immunoglobulin level / MGI
- asthenozoospermia / MGI
- abnormal immune system organ morphology / MGI
- decreased circulating luteinizing hormone level / MGI
- decreased circulating follicle stimulating hormone level / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal circulating gonadotropin level / MGI
- abnormal hair follicle development / MGI
- abnormal compact bone morphology / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cuticle / MGI
- abnormal hair cortex morphology / MGI
- hairless / MGI
- brittle hair / MGI
- abnormal venule morphology / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased length of allograft survival / MGI
- decreased skeletal muscle mass / MGI
- abnormal CD8-positive, alpha beta T cell morphology / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- decreased lymphocyte cell number / MGI
- decreased T cell number / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased double-negative T cell number / MGI
- increased double-positive T cell number / MGI
- decreased double-positive T cell number / MGI
- cachexia / MGI
- blepharitis / MGI
- ascites / MGI
- endocrine/exocrine gland phenotype / MGI
- immune system phenotype / MGI
- corneal vascularization / MGI
- absent T cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased single-positive T cell number / MGI
- lymph node hypoplasia / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-2 level / MGI
- reduced hair shaft melanin granule number / MGI
- abnormal spleen physiology / MGI
- abnormal splenic cell ratio / MGI
- chromosomal instability / MGI
- coiled sperm flagellum / MGI
- decreased skeletal muscle fiber size / MGI
- abnormal thymus epithelium morphology / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal hair cortex keratinization / MGI
- increased DN1 thymic pro-T cell number / MGI
- abnormal circulating cytokine level / MGI
- absent thymus cortex / MGI
- decreased lymphoma incidence / MGI
- increased plasmacytoma incidence / MGI
- abnormal hair follicle bulb morphology / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- integument phenotype / MGI
- postnatal lethality, incomplete penetrance / MGI
- increased or absent threshold for auditory brainstem response / MGI
- impaired spatial learning / MGI
- short nails / MGI
- nail dystrophy / MGI
- abnormal nail plate morphology / MGI
- abnormal nail matrix morphology / MGI
- absent thymus medulla / MGI
- thymus cysts / MGI
- abnormal corneocyte morphology / MGI
Literature references
- Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis.;Hirasawa T, Yamashita H, Makino S, ;1998;Experimental animals;47;63-7; 9498115
- Intracerebellar administration of the chemokine Cxcl3 reduces the volume of medulloblastoma lesions at an advanced stage by promoting the migration and differentiation of preneoplastic precursor cells.;Ceccarelli Manuela, Rossi Sabrina, Bonaventura Fabrizio, Massari Roberto, D'Elia Annunziata, Soluri Andrea, Micheli Laura, D'Andrea Giorgio, Mancini Barbara, Raspa Marcello, Scavizzi Ferdinando, Alaggio Rita, Del Bufalo Francesca, Miele Evelina, Carai Andrea, Mastronuzzi Angela, Tirone Felice, ;2024;Brain pathology (Zurich, Switzerland);0;e13283; 38946128