C3H.Cg-Fbxo11^Jf/H

Status	Available to order
EMMA ID	EM:00375
International strain name	C3H.Cg-Fbxo11^Jf/H
Alternative name	Jeff
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Fbxo11^Jf
Gene/Transgene symbol	Fbxo11

Information from provider

Provider	Rachel Hardisty
Provider affiliation	MRC Harwell, Didcot, Oxon, OX11 0RD
Phenotypic information	Mice carrying this mutation are small with a short face and are deaf.
References	A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.;Hardisty-Hughes Rachel E, Parker Andrew, Brown Steve D M, ;2010;Nature protocols;5;177-90; 20057387 A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.;Hardisty-Hughes Rachel E, Tateossian Hilda, Morse Susan A, Romero M Rosario, Middleton Alice, Tymowska-Lalanne Zuzanna, Hunter A Jackie, Cheeseman Michael, Brown Steve D M, ;2006;Human molecular genetics;15;3273-9; 17035249 Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.;Del-Pozo Jorge, MacIntyre Neil, Azar Ali, Glover James, Milne Elspeth, Cheeseman Michael, ;2019;Disease models & mechanisms;12;; 30898767 The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa.;Del-Pozo Jorge, Headon Denis J, Glover James D, Azar Ali, Schuepbach-Mallepell Sonia, Bhutta Mahmood F, Riddell Jon, Maxwell Scott, Milne Elspeth, Schneider Pascal, Cheeseman Michael, ;2022;Disease models & mechanisms;15;; 35107126

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

otitis media / DOID:10754

IMPC phenotypes (allele matching)

decreased bone mineral density / IMPC
abnormal retina morphology / IMPC
hyperactivity / IMPC
abnormal startle reflex / IMPC
increased startle reflex / IMPC
abnormal vocalization / IMPC
decreased mean corpuscular volume / IMPC
decreased circulating triglyceride level / IMPC
decreased heart weight / IMPC
abnormal bone mineralization / IMPC
thrombocytopenia / IMPC
abnormal locomotor activation / IMPC
abnormal defecation / IMPC
increased lean body mass / IMPC
decreased lean body mass / IMPC
decreased prepulse inhibition / IMPC
increased total body fat amount / IMPC
increased bone mineral content / IMPC
preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

decreased prepulse inhibition / IMPC
increased lean body mass / IMPC
decreased hematocrit / IMPC
thrombocytopenia / IMPC
decreased circulating iron level / IMPC
decreased heart weight / IMPC
increased total body fat amount / IMPC
abnormal startle reflex / IMPC
abnormal defecation / IMPC
abnormal locomotor activation / IMPC
increased startle reflex / IMPC
hyperactivity / IMPC
abnormal vocalization / IMPC
decreased hemoglobin content / IMPC
narrow eye opening / IMPC
preweaning lethality, complete penetrance / IMPC
decreased mean corpuscular volume / IMPC
increased bone mineral content / IMPC
decreased circulating calcium level / IMPC
decreased lean body mass / IMPC
decreased circulating triglyceride level / IMPC
decreased circulating total protein level / IMPC
decreased erythrocyte cell number / IMPC
short tibia / IMPC
abnormal retina morphology / IMPC
increased fasting circulating glucose level / IMPC
increased red blood cell distribution width / IMPC
decreased bone mineral density / IMPC
abnormal bone mineralization / IMPC

MGI phenotypes (allele matching)

short snout / MGI
decreased body weight / MGI
decreased body size / MGI
increased susceptibility to otitis media / MGI
deafness / MGI
abnormal cytokine secretion / MGI
abnormal auditory tube / MGI
decreased endocochlear potential / MGI
abnormal middle ear ossicle morphology / MGI
hearing/vestibular/ear phenotype / MGI
absent pinna reflex / MGI
abnormal tympanic cavity morphology / MGI
middle ear polyps / MGI
middle ear effusion / MGI
tympanic membrane retraction / MGI
excessive cerumen / MGI
abnormal pinna reflex / MGI
impaired hearing / MGI
midline facial cleft / MGI
cleft palate / MGI
eyelids open at birth / MGI
neonatal lethality, complete penetrance / MGI
neonatal lethality, incomplete penetrance / MGI
short face / MGI

MGI phenotypes (gene matching)

midline facial cleft / MGI
cleft palate / MGI
decreased hair follicle number / MGI
short snout / MGI
thick epidermis / MGI
epidermal hyperplasia / MGI
decreased body weight / MGI
decreased body size / MGI
eyelids open at birth / MGI
abnormal pinna reflex / MGI
decreased startle reflex / MGI
increased susceptibility to otitis media / MGI
deafness / MGI
abnormal cytokine secretion / MGI
abnormal auditory tube / MGI
decreased endocochlear potential / MGI
abnormal middle ear ossicle morphology / MGI
hearing/vestibular/ear phenotype / MGI
impaired hearing / MGI
absent pinna reflex / MGI
abnormal protein level / MGI
absent keratohyalin granules / MGI
neonatal lethality, complete penetrance / MGI
neonatal lethality, incomplete penetrance / MGI
perinatal lethality, incomplete penetrance / MGI
short face / MGI
abnormal tympanic cavity morphology / MGI
middle ear polyps / MGI
middle ear effusion / MGI
tympanic membrane retraction / MGI
excessive cerumen / MGI

Literature references

A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.;Hardisty-Hughes Rachel E, Parker Andrew, Brown Steve D M, ;2010;Nature protocols;5;177-90; 20057387
A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.;Hardisty-Hughes Rachel E, Tateossian Hilda, Morse Susan A, Romero M Rosario, Middleton Alice, Tymowska-Lalanne Zuzanna, Hunter A Jackie, Cheeseman Michael, Brown Steve D M, ;2006;Human molecular genetics;15;3273-9; 17035249
Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.;Del-Pozo Jorge, MacIntyre Neil, Azar Ali, Glover James, Milne Elspeth, Cheeseman Michael, ;2019;Disease models & mechanisms;12;985214; 30898767
The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa.;Del-Pozo Jorge, Headon Denis J, Glover James D, Azar Ali, Schuepbach-Mallepell Sonia, Bhutta Mahmood F, Riddell Jon, Maxwell Scott, Milne Elspeth, Schneider Pascal, Cheeseman Michael, ;2022;Disease models & mechanisms;15;; 35107126
Trans-cortical vessels in the mouse temporal bulla bone are a means to recruit myeloid cells in chronic otitis media and limit peripheral leukogram changes.;Azar Ali, Bhutta Mahmood F, Del-Pozo Jorge, Milne Elspeth, Cheeseman Michael, ;2022;Frontiers in genetics;13;; 36246635

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
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C3H.Cg-Fbxo11Jf/H