B6;C3-Fasl^gld/Orl

Status	Available to order
EMMA ID	EM:00036
International strain name	B6;C3-Fasl^gld/Orl
Alternative name	C57BL/6 - gld
Strain type	Spontaneous
Allele/Transgene symbol	Fasl^gld
Gene/Transgene symbol	Fasl

Information from provider

Provider	S Nagata
Provider affiliation	Osaka Bioscience Institute
Phenotypic information	Mutant strain for Fasl-gld (Fas ligand, generalized lymphoproliferative disease) allele; prev. nomenclature: Tnfsf6-gld (tumor necrosis factor ligand superfamily member 6, gld). The gld allele is generated by a point mutation in the C-terminal region of the Fasl protein. The homozygous gld mice develop lymphadenopathy and have autoimmune diseases.
References	Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.;Takahashi T, Tanaka M, Brannan C I, Jenkins N A, Copeland N G, Suda T, Nagata S, ;1994;Cell;76;969-76; 7511063

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

autoimmune lymphoproliferative syndrome / DOID:6688

MGI phenotypes (allele matching)

increased leukocyte cell number / MGI
increased neutrophil cell number / MGI
enlarged spleen / MGI
enlarged lymph nodes / MGI
anemia / MGI
skin edema / MGI
interstitial pneumonia / MGI
neoplasm / MGI
premature death / MGI
abnormal T cell differentiation / MGI
abnormal lymph node morphology / MGI
increased immunoglobulin level / MGI
increased IgG level / MGI
increased IgM level / MGI
increased IgA level / MGI
increased autoantibody level / MGI
increased anti-double stranded DNA antibody level / MGI
increased anti-nuclear antigen antibody level / MGI
increased lymphocyte cell number / MGI
increased T cell number / MGI
decreased B cell number / MGI
decreased cytotoxic T cell cytolysis / MGI
renal/urinary system phenotype / MGI
cardiovascular system phenotype / MGI
increased IgG1 level / MGI
increased IgG2a level / MGI
increased IgG2b level / MGI
mortality/aging / MGI
decreased granulocyte number / MGI
abnormal hepatocyte morphology / MGI
demyelination / MGI
abnormal osteoclast physiology / MGI
focal hepatic necrosis / MGI
brain inflammation / MGI
eye inflammation / MGI
liver inflammation / MGI
increased susceptibility to bacterial infection / MGI
increased susceptibility to viral infection / MGI
abnormal sperm number / MGI
decreased circulating alanine transaminase level / MGI
abnormal sperm physiology / MGI
abnormal eye electrophysiology / MGI
CNS inflammation / MGI
decreased hepatocyte apoptosis / MGI
abnormal NK cell physiology / MGI
abnormal T cell physiology / MGI
decreased neuron apoptosis / MGI
abnormal T cell proliferation / MGI
abnormal T cell morphology / MGI
abnormal interleukin level / MGI
impaired macrophage phagocytosis / MGI
increased spleen weight / MGI
homeostasis/metabolism phenotype / MGI
increased apoptosis / MGI
dermatitis / MGI
increased IgE level / MGI
increased susceptibility to systemic lupus erythematosus / MGI
decreased susceptibility to injury / MGI
immune system phenotype / MGI
increased circulating tumor necrosis factor level / MGI
increased histiocytic sarcoma incidence / MGI
reproductive system phenotype / MGI

MGI phenotypes (gene matching)

increased leukocyte cell number / MGI
increased neutrophil cell number / MGI
decreased granulocyte number / MGI
enlarged liver / MGI
abnormal hepatocyte morphology / MGI
abnormal salivary gland morphology / MGI
lymphoid hyperplasia / MGI
enlarged spleen / MGI
enlarged lymph nodes / MGI
enlarged thymus / MGI
demyelination / MGI
dermatitis / MGI
increased metastatic potential / MGI
abnormal osteoclast physiology / MGI
anemia / MGI
focal hepatic necrosis / MGI
skin edema / MGI
impaired macrophage phagocytosis / MGI
abnormal humoral immune response / MGI
decreased IgG level / MGI
autoimmune response / MGI
brain inflammation / MGI
eye inflammation / MGI
liver inflammation / MGI
interstitial pneumonia / MGI
neoplasm / MGI
premature death / MGI
abnormal definitive hematopoiesis / MGI
abnormal T cell differentiation / MGI
no abnormal phenotype detected / MGI
abnormal lymph node morphology / MGI
abnormal double-negative T cell morphology / MGI
increased susceptibility to bacterial infection / MGI
increased susceptibility to viral infection / MGI
abnormal T cell physiology / MGI
increased immunoglobulin level / MGI
increased IgG level / MGI
increased IgM level / MGI
increased IgA level / MGI
increased IgE level / MGI
abnormal sperm number / MGI
glomerulonephritis / MGI
decreased circulating alanine transaminase level / MGI
increased urine protein level / MGI
decreased neuron apoptosis / MGI
increased autoantibody level / MGI
abnormal sperm physiology / MGI
increased anti-double stranded DNA antibody level / MGI
increased anti-nuclear antigen antibody level / MGI
increased susceptibility to systemic lupus erythematosus / MGI
increased spleen weight / MGI
increased lymphocyte cell number / MGI
increased T cell number / MGI
decreased B cell number / MGI
abnormal cytotoxic T cell physiology / MGI
decreased cytotoxic T cell cytolysis / MGI
abnormal T cell proliferation / MGI
increased B cell proliferation / MGI
decreased susceptibility to injury / MGI
increased T cell proliferation / MGI
renal/urinary system phenotype / MGI
homeostasis/metabolism phenotype / MGI
cardiovascular system phenotype / MGI
immune system phenotype / MGI
reproductive system phenotype / MGI
vision/eye phenotype / MGI
abnormal eye electrophysiology / MGI
increased apoptosis / MGI
CNS inflammation / MGI
abnormal retinal nerve fiber layer morphology / MGI
decreased retinal ganglion cell number / MGI
increased liver tumor incidence / MGI
abnormal T cell morphology / MGI
abnormal retinal ganglion cell morphology / MGI
retinal ganglion cell degeneration / MGI
increased plasma cell number / MGI
increased germinal center B cell number / MGI
increased IgG1 level / MGI
increased IgG2a level / MGI
increased IgG2b level / MGI
increased circulating tumor necrosis factor level / MGI
abnormal interleukin level / MGI
abnormal thymus cell ratio / MGI
decreased hepatocyte apoptosis / MGI
increased histiocytic sarcoma incidence / MGI
abnormal NK cell physiology / MGI
mortality/aging / MGI
renal cast / MGI
glomerular crescent / MGI
increased lymphoma incidence / MGI
impaired humoral immune response / MGI
increased retinal apoptosis / MGI

Literature references

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.;Takahashi T, Tanaka M, Brannan C I, Jenkins N A, Copeland N G, Suda T, Nagata S, ;1994;Cell;76;969-76; 7511063

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6;C3-Faslgld/Orl