B6.129P2-Gjc1tm1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:00331 |
International strain name | B6.129P2-Gjc1tm1Kwi/Cnrm |
Alternative name | Cx45 KO (LacZ) |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Gjc1tm1Kwi |
Gene/Transgene symbol | Gjc1 |
Information from provider
Provider | Klaus WILLECKE |
Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
Genetic information | Exon 3, including the whole open reading frame of Cx45 (Gjc1), is homologously replaced by the lacZ open reading frame. The selection marker gene (neo) is still in the genome. |
Phenotypic information | Embryonic lethal at 10.5 dpc, caused by endothelium malformation. |
Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal heart development / MGI
- abnormal heart looping / MGI
- enlarged heart / MGI
- absent trabeculae carneae / MGI
- absent atrioventricular cushions / MGI
- impaired hematopoiesis / MGI
- decreased embryo size / MGI
- embryonic growth arrest / MGI
- thin myocardium / MGI
- no phenotypic analysis / MGI
- decreased cardiac output / MGI
- embryonic growth retardation / MGI
- small placenta / MGI
- decreased cardiac muscle contractility / MGI
- increased apoptosis / MGI
- heart block / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- increased embryonic neuroepithelium apoptosis / MGI
Literature references
- Defective vascular development in connexin 45-deficient mice.;Krüger O, Plum A, Kim J S, Winterhager E, Maxeiner S, Hallas G, Kirchhoff S, Traub O, Lamers W H, Willecke K, ;2000;Development (Cambridge, England);127;4179-93; 10976050
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