- abnormal nervous system electrophysiology / MGI
- decreased insulin secretion / MGI
- abnormal retinal ganglion layer morphology / MGI
- digestive/alimentary phenotype / MGI
- abnormal cued conditioning behavior / MGI
- abnormal single cell response / MGI
- abnormal nerve fiber response / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal insulin secretion / MGI
- behavior/neurological phenotype / MGI
B6.129P2-Gjd2tm1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:00326 |
Citation information | RRID:IMSR_EM:00326 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | B6.129P2-Gjd2tm1Kwi/Cnrm |
Alternative name | Cx36 KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Gjd2tm1Kwi |
Gene/Transgene symbol | Gjd2 |
Information from provider
Provider | Klaus WILLECKE |
Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
Genetic information | Exon 2, including most of the open reading frame of Cx36 (Gjd2), is homologously replaced by a two loxP sites-flanked selection marker gene (HPRT), which is still in the genome. |
Phenotypic information | Visual transmission defect. |
Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal cued conditioning behavior / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal inhibitory postsynaptic potential / MGI
- abnormal excitatory postsynaptic potential / MGI
- no phenotypic analysis / MGI
- decreased insulin secretion / MGI
- abnormal single cell response / MGI
- abnormal nerve fiber response / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal insulin secretion / MGI
- nervous system phenotype / MGI
- abnormal brain wave pattern / MGI
- abnormal retinal ganglion layer morphology / MGI
- endocrine/exocrine gland phenotype / MGI
- digestive/alimentary phenotype / MGI
- behavior/neurological phenotype / MGI
- vision/eye phenotype / MGI
- abnormal action potential / MGI
Literature references
- Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36.;Güldenagel M, Ammermüller J, Feigenspan A, Teubner B, Degen J, Söhl G, Willecke K, Weiler R, ;2001;The Journal of neuroscience : the official journal of the Society for Neuroscience;21;6036-44; 11487627
- The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte coupling in mice.;Pelz Laura, Dossou Laura, Kompier Nine, Jüttner René, Siemonsmeier Gabrielle, Meyer Niklas, Lowenstein Elijah D, Lahmann Ines, Kettenmann Helmut, Birchmeier Carmen, Rathjen Fritz G, ;2024;eNeuro;11;; 38388443
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