- abnormal nervous system electrophysiology / MGI
- decreased insulin secretion / MGI
- abnormal retinal ganglion layer morphology / MGI
- digestive/alimentary phenotype / MGI
- abnormal cued conditioning behavior / MGI
- abnormal single cell response / MGI
- abnormal nerve fiber response / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal insulin secretion / MGI
- behavior/neurological phenotype / MGI
B6.129P2-Gjd2tm1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:00326 |
International strain name | B6.129P2-Gjd2tm1Kwi/Cnrm |
Alternative name | Cx36 KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Gjd2tm1Kwi |
Gene/Transgene symbol | Gjd2 |
Information from provider
Provider | Klaus WILLECKE |
Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
Genetic information | Exon 2, including most of the open reading frame of Cx36 (Gjd2), is homologously replaced by a two loxP sites-flanked selection marker gene (HPRT), which is still in the genome. |
Phenotypic information | Visual transmission defect. |
Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal cued conditioning behavior / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal inhibitory postsynaptic potential / MGI
- abnormal excitatory postsynaptic potential / MGI
- no phenotypic analysis / MGI
- decreased insulin secretion / MGI
- abnormal single cell response / MGI
- abnormal nerve fiber response / MGI
- abnormal pancreatic beta cell physiology / MGI
- abnormal insulin secretion / MGI
- nervous system phenotype / MGI
- abnormal brain wave pattern / MGI
- abnormal retinal ganglion layer morphology / MGI
- endocrine/exocrine gland phenotype / MGI
- digestive/alimentary phenotype / MGI
- behavior/neurological phenotype / MGI
- vision/eye phenotype / MGI
- abnormal action potential / MGI
Literature references
- Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36.;Güldenagel M, Ammermüller J, Feigenspan A, Teubner B, Degen J, Söhl G, Willecke K, Weiler R, ;2001;The Journal of neuroscience : the official journal of the Society for Neuroscience;21;6036-44; 11487627
- The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated astrocyte-astrocyte coupling in mice.;Pelz Laura, Dossou Laura, Kompier Nine, Jüttner René, Siemonsmeier Gabrielle, Meyer Niklas, Lowenstein Elijah D, Lahmann Ines, Kettenmann Helmut, Birchmeier Carmen, Rathjen Fritz G, ;2024;eNeuro;11;; 38388443
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