| Status | Available to order |
| EMMA ID | EM:00324 |
| International strain name | B6.129-Gjb3tm1Kwi/Cnrm |
| Alternative name | Cx31 KO (LacZ) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gjb3tm1Kwi |
| Gene/Transgene symbol | Gjb3 |
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | Exon 2, including the whole open reading frame of Cx31 (Gjb3), is homologously replaced by the lacZ open reading frame and a MCI promotor-controlled neo selection marker gene, which is still in the genome. |
| Phenotypic information | Transient placental dysmorphogenesis resulting in reduced offspring. |
| Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times. |
| References |
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| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | Backcrossed to C57BL/6J |
Orphanet associated rare diseases, based on orthologous gene matching
