| Status | Available to order |
| EMMA ID | EM:00324 |
| Citation information | RRID:IMSR_EM:00324 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Gjb3tm1Kwi/Cnrm |
| Alternative name | Cx31 KO (LacZ) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gjb3tm1Kwi |
| Gene/Transgene symbol | Gjb3 |
| Provider | Klaus WILLECKE |
| Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
| Genetic information | Exon 2, including the whole open reading frame of Cx31 (Gjb3), is homologously replaced by the lacZ open reading frame and a MCI promotor-controlled neo selection marker gene, which is still in the genome. |
| Phenotypic information | Transient placental dysmorphogenesis resulting in reduced offspring. |
| Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times. |
| References |
|
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | Backcrossed to C57BL/6J |
Orphanet associated rare diseases, based on orthologous gene matching
