B6.Cg-Gphntm1Jrs Tg(ACTB-At5g20990)17Betz/Cnrm

Status

Available to order

EMMA IDEM:00316
Citation informationRRID:IMSR_EM:00316 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.Cg-Gphntm1Jrs Tg(ACTB-At5g20990)17Betz/Cnrm
Alternative nameCnx1tg17
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolGphntm1Jrs, Tg(ACTB-At5g20990)17Betz
Gene/Transgene symbolGphn, Tg(ACTB-At5g20990)17Betz

Information from provider

ProviderHeinrich Betz
Provider affiliationMax Planck Institute fuer Biophysikalische Chemie
Genetic informationThe Cnx1 (At5g20990)-espressing transgenic strains were initially generated by crossing the founders with B6D2F2. Subsequently, strains from founders 12 and 17 were crossed with heterozygous gephyrin +/- mice, which had also been maintained on a B6D2F6 background. Subsequently, both the Cnx1 n. 12 and n. 17 strains have been crossed with gephyrin +/- mice, which have been maintained on a B6 background.
Phenotypic informationCNX1/At5g20990 is the Arabidopsis thaliana plant ortholog of gephyrin, a protein which is involved the clustering/aggregation of inhibitory receptors. Cnx1-expressing transgenic strains were used to assess whether its expression would rescue the lethality of gephyrin knock-out mice.
References
  • Rescue of molybdenum cofactor biosynthesis in gephyrin-deficient mice by a Cnx1 transgene.;Grosskreutz Yannick, Betz Heinrich, Kneussel Matthias, ;2003;Biochemical and biophysical research communications;301;450-5; 12565882

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal motor neuron morphology / MGI
  • motor neuron degeneration / MGI
  • decreased motor neuron number / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal axon extension / MGI
  • abnormal retinal inner plexiform layer morphology / MGI
  • increased motor neuron number / MGI
  • hyperresponsive / MGI
  • abnormal suckling behavior / MGI
  • abnormal posture / MGI
  • abnormal vocalization / MGI
  • apnea / MGI
  • neonatal lethality, complete penetrance / MGI
MGI phenotypes (gene matching)
  • abnormal motor neuron morphology / MGI
  • motor neuron degeneration / MGI
  • decreased motor neuron number / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • hyperresponsive / MGI
  • abnormal suckling behavior / MGI
  • abnormal posture / MGI
  • abnormal vocalization / MGI
  • apnea / MGI
  • no abnormal phenotype detected / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal axon extension / MGI
  • abnormal retinal inner plexiform layer morphology / MGI
  • increased motor neuron number / MGI
  • neonatal lethality, complete penetrance / MGI

Literature references

  • Rescue of molybdenum cofactor biosynthesis in gephyrin-deficient mice by a Cnx1 transgene.;Grosskreutz Yannick, Betz Heinrich, Kneussel Matthias, ;2003;Biochemical and biophysical research communications;301;450-5; 12565882

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).