B6.FVB-Tg(tetO-NR3C1)#Frje/Orl
| Status | Available to order |
| EMMA ID | EM:03108 |
| Citation information | RRID:IMSR_EM:03108 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.FVB-Tg(tetO-NR3C1)#Frje/Orl |
| Alternative name | Tg(lacZ-TetO-hGR) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-NR3C1)#Frje |
| Gene/Transgene symbol | Tg(tetO-NR3C1)#Frje |
Information from provider
| Provider | Francois Tronche |
| Provider affiliation | Molecular Genetics Neurophysiology and Behavior, CNRS CNRS UMR7224 |
| Additional owner | Frederic Jaisser, INSERM |
| Genetic information | Mice carrying the bidirectional tetO-hGR transgene express, concomitantly, lacZ and human glucocorticoid receptors upon tTA activation. This approach proved to be efficient in forebrain neurons, heart muscles and pancreatic cells. |
| Phenotypic information | We did not observe any phenotype in animals carrying Tg(TetO-hGR). |
| Breeding history | Backcrossed into C57BL/6 for five generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous males, wild-type C57BL/6J females |
Literature references
- Conditional glucocorticoid receptor expression in the heart induces atrio-ventricular block.;Sainte-Marie Yannis, Nguyen Dinh Cat Aurelie, Perrier Romain, Mangin Laurence, Soukaseum Christelle, Peuchmaur Michel, Tronche François, Farman Nicolette, Escoubet Brigitte, Benitah Jean-Pierre, Jaisser Frederic, ;2007;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;21;3133-41; 17517920