B6.FVB-Tg(tetO-NR3C1)#Frje/Orl
| Status | Available to order |
| EMMA ID | EM:03108 |
| International strain name | B6.FVB-Tg(tetO-NR3C1)#Frje/Orl |
| Alternative name | Tg(lacZ-TetO-hGR) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-NR3C1)#Frje |
| Gene/Transgene symbol | Tg(tetO-NR3C1)#Frje |
Information from provider
| Provider | Francois Tronche |
| Provider affiliation | Molecular Genetics Neurophysiology and Behavior, CNRS CNRS UMR7224 |
| Additional owner | Frederic Jaisser, INSERM |
| Genetic information | Mice carrying the bidirectional tetO-hGR transgene express, concomitantly, lacZ and human glucocorticoid receptors upon tTA activation. This approach proved to be efficient in forebrain neurons, heart muscles and pancreatic cells. |
| Phenotypic information | We did not observe any phenotype in animals carrying Tg(TetO-hGR). |
| Breeding history | Backcrossed into C57BL/6 for five generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous , wild-type C57BL/6J |
Literature references
- Conditional glucocorticoid receptor expression in the heart induces atrio-ventricular block.;Sainte-Marie Yannis, Nguyen Dinh Cat Aurelie, Perrier Romain, Mangin Laurence, Soukaseum Christelle, Peuchmaur Michel, Tronche François, Farman Nicolette, Escoubet Brigitte, Benitah Jean-Pierre, Jaisser Frederic, ;2007;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;21;3133-41; 17517920