IMPC phenotypes (gene matching)
B6.129-B2mtm1Unc H2-Ab1b-tm1Doi/DoiOrl
| Status | Available to order |
| EMMA ID | EM:00030 |
| Citation information | RRID:IMSR_EM:00030 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-B2mtm1Unc H2-Ab1b-tm1Doi/DoiOrl |
| Alternative name | beta2m°, Abeta°(MHC) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | H2-Ab1b-tm1Doi, B2mtm1Unc |
| Gene/Transgene symbol | H2-Ab1, B2m |
Information from provider
| Provider | Diane MATHIS |
| Provider affiliation | LGME Universite |
| Phenotypic information | Double-mutant mice deficient in products of beta-2 microglobulin, and histocompatibility 2, class II antigen A, beta 1 (MHC class I and II) genes. Obtained by crossing of strains carrying the B2m and H2-Ab1 gene mutations. They generally show a deficiency in T lymphocytes (CD4 and CD8 compartments). |
| Breeding history | 129P2/OlaHsd and 129S2/SvPas ES cells; 9 generations of backcross to C57BL/6, then intercross. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
MGI phenotypes (allele matching)
- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
MGI phenotypes (gene matching)
- absent CD8-positive, alpha-beta T cells / MGI
- decreased IgG level / MGI
- decreased level of surface class I molecules / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
- increased IgM level / MGI
- insulitis / MGI
- abnormal lateral geniculate nucleus morphology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to parasitic infection / MGI
- abnormal cytotoxic T cell physiology / MGI
- abnormal pancreatic beta cell morphology / MGI
- decreased circulating serum albumin level / MGI
- hemochromatosis / MGI
- abnormal T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased T-helper 1 cell number / MGI
- increased gamma-delta T cell number / MGI
- increased gamma-delta intraepithelial T cell number / MGI
- increased tumor necrosis factor secretion / MGI
- increased interleukin-3 secretion / MGI
- decreased interleukin-4 secretion / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- abnormal immune system cell morphology / MGI
- hemolytic anemia / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- autoimmune response / MGI
- reduced fertility / MGI
- premature death / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal dendritic cell physiology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal dendritic cell antigen presentation / MGI
- abnormal B cell physiology / MGI
- abnormal immunoglobulin level / MGI
- increased IgM level / MGI
- abnormal immune system organ morphology / MGI
- increased urine protein level / MGI
- abnormal cytokine secretion / MGI
- abnormal artery development / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- absent CD4-positive, alpha beta T cells / MGI
- abnormal lymphocyte physiology / MGI
- insulitis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-single stranded DNA antibody level / MGI
- increased anti-erythrocyte antigen antibody level / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to experimental autoimmune myasthenia gravis / MGI
- decreased regulatory T cell number / MGI
- increased B cell number / MGI
- decreased susceptibility to parasitic infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal level of surface class II molecules / MGI
- increased double-negative T cell number / MGI
- decreased susceptibility to autoimmune disorder / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- abnormal response to transplant / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interleukin-12 secretion / MGI
- abnormal lymph node cell ratio / MGI
- abnormal neuron proliferation / MGI
Literature references
- Another view of the selective model of thymocyte selection.;Chan S H, Cosgrove D, Waltzinger C, Benoist C, Mathis D, ;1993;Cell;73;225-36; 8097430